Clinical Chemistry

A Reference Measurement System for Apolipoproteins

Image credit: European Bioinformatics Institute

C.M. Cobbaert, H. Althaus, I. Begcevic Brkovic, et al. outline a conceptual approach aimed at achieving a novel, multiplexed reference measurement system for seven serum apolipoproteins.

Predicting Mortality Risk in Healthy People

N. Pho, A.K. Manrai, J.T. Leppert, et al. have found that reference and nonoutlying variations in common biomarkers are consistently associated with mortality risk in healthy Americans, but their additive contribution in explaining mortality risk is minor.

Defining Classification Criteria for ATM Variants

L. Feliubadaló, A. Moles-Fernández, M. Santamariña-Pena, et al. initiated a collaborative effort to improve and standardize variant classification for the ATM gene, which is included in most hereditary cancer panels.

Harmonization of Serum Total and Free PSA

S. Ferraro, M. Bussetti, S. Rizzardi, et al. demonstrate that the harmonization among total PSA measuring systems is acceptable only when minimum analytical performance specifications are applied and necessitates further improvement.