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Continuous Renal Replacement Therapies (CRRT)

A lab is validating ionized calcium for CRRT treatment for the purpose of monitoring the efficacy of citrate in the circuit dose. Would this be considered off-label? One respondent says, if the specimen is blood mixed with citrate from the circuit, it would not be considered an LDT but simply another sample source, such as arterial vs. venous. Therefore, the lab can add a disclaimer explaining the source and how the iCa levels are not representative of systemic levels but are from a CRRT circuit.


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AACC is a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. Our leadership in education, advocacy and collaboration helps lab professionals adapt to change and do what they do best: provide vital insight and guidance so patients get the care they need.