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FEATURED AACC ARTERY DISCUSSION

Gabapentin Nonlinear Calibration Curve

One lab has had a LC-MS/MS serum gabapentin quantification assay since 2015, but recently the calibration curve became quadratic instead of linear. What could have caused this? One respondent suggests several potential reasons, from an aging detector to an inadvertent change in the curve weighting setting that could make a curve appear to fit better with a quadratic rather than a linear equation. To try to pinpoint the cause, he suggests comparing the gabapentin and ISTD raw signal areas before and after the problem started.

AACC LEARNING LAB

Free Course on COVID-19

AACC developed this content with leading scientists as part of AACC Learning Lab on NEJM Knowledge+. The free course covers COVID-19 transmission, complications, diagnosis, and more.

About AACC

AACC is a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. Our leadership in education, advocacy and collaboration helps lab professionals adapt to change and do what they do best: provide vital insight and guidance so patients get the care they need.