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Membership & Community

RECENT Artery Conversations

Sweat Chloride Testing

We are in the process of replacing our old Gibson Cooke Iontophoresis Apparatus used for the collection of sweat for sweat chloride testing.  We would like to keep using our Buchler Digital Chloridometer with the Macroduct Advance System from ELITech.  We are having issues developing a procedure for analysis based on the sweat volumes collected on the Macroduct collection device. Are there any users out here that are currently using this combination?

Calculating TIBC and % SAT when ferritin > 1200 μg/L?

Roche UIBC package insert (2018-10, V8.0 English) states that "In the presence of high ferritin concentration > 1200 μg/L the assumption that serum iron is almost completely bound to transferrin is not valid anymore. Therefore, such iron results should not be used to calculate Total Iron Binding Capacity (TIBC) or percent transferrin saturation (% SAT)." I did not see a similar statement in Abbott UIBC package insert. From the reference that Roche cited (Tietz NW et al., Clin Chem 1996;42:109-111.), I only saw a negative bias on the ICSH 1990 manual reference iron method compared with a couple of automatic methods when ferritin > 1200 μg/L. The authors inferred one possibility was the interference by ferritin on iron assay. Do you follow this manufacturer's recommendation?

Total bile acids testing platforms and vendors for cholestasis in pregnancy

One issue that came up recently is that 1 of the bile acid assays indicate that samples cannot be processed if the patient is being treated with ursodeoxycholic acid. This is a problem as many of our women that have elevated bile acids will be on Urso and will need follow up of their BA levels. Is there a solution for this? Is there a more suitable assay available?


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