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Standardization of COVID-19 Serological Assays: Establishment of the WHO International Standard and its Importance

  • Credit:1.0 ACCENT
  • Duration: 1 Hour
  • Date:DEC.7.2021 11:30 a.m. - 12:30 p.m.
  • Level: Intermediate

Price: $0.00

Member Price: $0.00

Register for this webinar to learn about the SARS-CoV-2 antibody standardized testing. With your registration, you will have access to the recording on demand through December 31, 2022.


Since the beginning of the pandemic, hundreds of serological tests have been developed, including more than 80 tests that received U.S. Food and Drug Administration Emergency Use Authorization. These tests represent different formats and have different viral antigen targets. The tests also detect different antibody isotypes and report qualitative or semi-quantitative or quantitative test results. Hundreds of studies have been published using multiple antibody assays, however, it is challenging to compare results or aggregate data since the assays were not calibrated to an international standard.

To address this challenge, the World Health Organization (WHO) generated an International Standard for SARS-CoV-2 antibodies. This webinar will provide attendees with an overview of how this standard was developed, how it supports serological assay development, and its role in the pandemic. The calibration of serological assays to a common unitage will improve our understanding of the virus epidemiology, and vaccine and therapeutic efficacies.


This activity is designed for Physicians, Lab Supervisors, Lab Directors (and/or assistant directors), Lab Managers (supervisory and/or non-supervisory), Pathologists, Fellows, In-training Individuals, and researchers.


At the end of this activity, participants will be able to:

  • Describe the methodology used to establish the WHO International Standard and Reference Panel for anti-SARS-CoV-2 serological tests
  • Describe what it means to have a standardized assay
  • Explain the importance of standardized COVID-19 assays in the scientific and clinical communities
  • Describe upcoming changes to the current WHO International Standard and Reference Panel


Giada MattiuzzoGiada Mattiuzzo, PhD
Senior Scientist, National Institute for Biological Standards and Control-MHRA
South Mimms, Hertfordshire, UK


AACC is dedicated to ensuring balance, independence, objectivity, and scientific rigor in all educational activities. All participating planning committee members and faculty are required to disclose to the program audience any financial relationships related to the subject matter of this program. Disclosure information is reviewed in advance in order to manage and resolve any possible conflicts of interest. The intent of this disclosure is to provide participants with information on which they can make their own judgments.

The following faculty and reviewer reported no relevant financial relationship:

  • Giada Mattiuzzo, PhD


All recommendations involving clinical medicine are based on evidence accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients; AND/OR all scientific research referred to or reported in support or justification of a patient care recommendation conforms to generally accepted standards of experimental design, data collection, and analysis.


This activity is approved for 1.0 ACCENT® continuing education credits. Activity ID# 4020. This activity was planned in accordance with ACCENT® Standards and Policies.


Verification of Participation certificates are provided to registered participants based on completion of the activity, in its entirety, and the activity evaluation. For questions regarding continuing education, please email [email protected].

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