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Advancing Quantitative Measures of Monocyte Response to Infection from Academic Pursuit to Clinical Practice: The Time Is Now

  • Credit:1.5 ACCENT Credit
  • Duration: 1.5 hours
  • Date:DEC.14.2020 12:00 PM - 01:30 PM
  • Level: Intermediate

Price: $0.00

Member Price: $0.00

Rating: Member Average

This program, supported by Beckman Coulter, was originally presented during the 2020 AACC Annual Scientific Meeting, held virtually from December 13-17, 2020.


Monocytes are the key component of the innate immune response to infection, exhibiting complex, time-dependent differentiating behavior. Monocytes Distribution Width (MDW), quantitative measure of variability in monocyte morphology, has recently received regulatory clearance for diagnosis of adult sepsis in Emergency Department and has been studied in other patient types, including those emerging in current COVID-19 pandemic. The goal of the session is to connect current understanding of monocyte hematopathology with current evidence and practical aspects of use in the clinical practice across patient presentations.


This activity is designed for Lab Supervisors, Lab Directors (and/or Assistant Directors), Lab Managers (supervisory and/or non-supervisory), Point-of-Care Coordinators, Pathologists, and other laboratory professionals overseeing and/or carrying out topic.


At the end of this activity, participants will be able to:

  • Discuss monocyte biology including immune-phenotypical and morphological changes in infections and other reactive conditions.
  • Apply clinical evidence and incorporate practical aspects of using Monocyte Distribution Width (MDW) for sepsis diagnostics in the Emergency Department setting.
  • Understand the role of laboratory champions in educating physicians and improving prevailing practice.


Headshot of Magdalena Czader, MD, PhDMagdalena Czader, MD, PhD
Professor of Pathology & Laboratory Medicine
Indiana University School of Medicine
Indianapolis, IN

Headshot of Daniel Irimia, MD, MBChB, FCAPDaniel Irimia, MD, PhD
Associate Professor  
Center for Engineering in Medicine and Surgery,
Massachusetts General Hospital (MGH),
Harvard Medical School, and Shriners Hospitals for Children
Director, BioMEMS Core at MGH
Boston, MA 

Headshot of Jailan Osman, MD, PhDJailan Osman, MD
Service Chief AND Clinical Medical Director Pathology & Laboratory Medicine Service
Columbia VA Health Care System
Columbia, SC



AACC is dedicated to ensuring balance, independence, objectivity, and scientific rigor in all educational activities. All participating planning committee members and faculty are required to disclose to the program audience any financial relationships related to the subject matter of this program. Disclosure information is reviewed in advance in order to manage and resolve any possible conflicts of interest. The intent of this disclosure is to provide participants with information on which they can make their own judgments.

The following faculty and reviewers reported no relevant financial relationship:
Magdalena Czader, MD, PhD; Daniel Irimia, MD, MBChB, FCAP; Jailan Osman, MD, PhD


All recommendations involving clinical medicine are based on evidence accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients; AND/OR All scientific research referred to or reported in support or justification of a patient care recommendation conforms to generally accepted standards of experimental design, data collection, and analysis.


This activity is approved for 1.5 ACCENT® continuing education credits. Activity ID# 2055. This activity was planned in accordance with ACCENT® Standards and Policies.

Release date: December 14, 2020
Credit valid through: December 31, 2021


Verification of Participation certificates are provided to registered participants based on completion of the activity, in its entirety, and the activity evaluation. For questions regarding continuing education, please email [email protected].

Supported By

Beckman Coulter