A 45-year-old man with a history of multiple myeloma and hypertension presented for mobilization and collection of hematopoietic progenitor cells (HPCs) by apheresis. Serum from a blood specimen obtained at the time of HPC collection and the HPC plasma collection bag after 24 h of refrigerated storage are shown below.

  1. What conditions could cause serum and plasma specimens to have this appearance?
  2. What can be done to investigate the cause of this phenomenon?
  3. Could this collection be used?

What Is Your Guess? Read the article by Christopher R. McCudden and Yara A. Park here for the answers.