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Multiplexing Homocysteine Into Newborn Screening Assays

Classical homocystinuria (HCU) results from deficient cystathionine β-synthase activity, causing elevated levels of methionine and homocysteine. Newborn screening aims to identify HCU in pre-symptomatic newborns by assessing methionine as a first-tier biomarker.


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AACC is a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. Our leadership in education, advocacy and collaboration helps lab professionals adapt to change and do what they do best: provide vital insight and guidance so patients get the care they need.