Issue

Chemicals can derange the endocrine system in multiple ways, leading to reproductive and cognitive impairment, cancer, and even obesity. Many studies have examined endocrine disrupting chemicals (EDCs) and their impact on human health, but a universal method that synthesizes this data has eluded researchers. A panel of experts sought to…

Combing through several influential clinical journals, researchers made an unsettling discovery: Very little information exists on the analytical characteristics of biomarkers or on the developers of biomarker measurement procedures. The results, which have implications for effectively interpreting and replicating studies, show that “we have limited understanding of the people who…

A large multisite analysis that compared toxin-positive enzyme immunoassay and nucleic acid amplification test (NAAT)-positive-only results for Clostridioides difficile (CDI) infection found more severe disease and greater risk of recurrence among toxin-positive cases but no differences between the two methods in adjusted rates of infection-related complications or mortality. The results,…

Ovarian cancer has proven to be an elusive foe: Women often aren’t diagnosed until the late stages of disease, and less than 50% of all patients survive 5 years following diagnosis. Cancer antigen 125 (CA125), a serum biomarker test linked to increased risk of ovarian cancer, had never been thoroughly…