Using LC-MS/MS versus Immunoassay for Thyroid Testing

  • Duration: 43 minutes

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This is a recorded version of an AACC live webinar that was held November 20, 2014. In this on-demand webinar, NIH researcher Dr. Steven Soldin discusses what researchers are learning from using liquid chromatography tandem mass spectrometry (LC/MS-MS) to perform thyroid function tests. Dr. Soldin describes the advantages and disadvantages of performing these assays on an LC/MS-MS platform versus performing them on the more traditional immunoassay platforms, and outlines how immunoassay and tandem mass spectrometry methods differ in terms of measuring FT4 and FT3 vs log TSH and describe the shortcomings of current immunoassay methodologies, as well as how they impact the diagnosis and treatment of various thyroid diseases. Also included in this program is information on how to test patients with deiodinase deficiencies; what researchers are learning about how to correctly diagnose subclinical hypothyroidism with today's methodologies; and how to detect and manage the effects of protein abnormalities (i.e., thyroxine binding globulin, albumin and prealbumin) on immunoassays and mass spec assays.