It is widely believed that the majority of clinical decisions are taken on the basis of data produced from the clinical laboratory. However, the real importance of laboratory medicine lies in bridging the knowledge gap at the clinician-laboratory interface. This session will give an overview of the role of laboratory professionals in the laboratory/clinician interface and will then present case studies which focus on the principles of clinical problem-solving and ways to develop the clinician/laboratorian interface. The key elements of developing a strong interface are Comments, Consultation and Collaboration. These aspects will be highlighted in this course through Endocrine Case studies.