Stratification for Pre-eclampsia: Lessons Learned from Translation of a Metabolomics Discovery to a Robust LC-MS/MS Test

  • Duration: 60 Minutes
  • Date:FEB.29.2016 9:00 AM - 10:00 AM

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This program will highlight the clinical research experiences of Metabolomic Diagnostics, an early stage company dedicated to translational biomarker research in the field of pregnancy complications.

Robin Tuytten

We’ll examine the company’s first research program, which is focused on the possibility of stratifying for pre-eclampsia risk early in pregnancy using metabolite profiles obtained from plasma samples.


Robin Tuytten, PhD, Vice President of Research and Development, Metabolomic Diagnostics, Ltd. (Cork, Ireland).

More Information


Join AACC and Metabolomic Diagnostics’ Director of R&D, Dr. Robin Tuytten, for an informative look at what it takes to translate the results of an unbiased metabolomics discovery study into a robust analytical pipeline centered around a research-use-only, semi-quantitative LC-MS/MS methodology.

Topics to be presented include:

  • Why it makes sense to employ multi-marker solutions for predicting pre-eclampsia
  • Developing a clinical research pipeline for assaying endogenous analytes
  • Optimizing use of Stable Isotope Labelled internal standards
  • Advanced MRM modes for achieving sufficient sampling across chromatographic peaks
  • Observations regarding the formulation of QC samples when working with bio-banked samples

Target Audience

This webinar is intended for laboratory administrators, directors, and managers; pathologists; clinicians; and IVD industry professionals who are involved in the evaluation, purchase, validation and/or oversight of mass spectrometry systems in a clinical research setting.

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