AACC uses Cookies to ensure the best website experience. Continuing without changing Cookie settings assumes you consent to our use of cookies on this device. You can change these settings at any time, but that may impair functionality on our websites. Review our cookie and privacy policy

More Coronavirus Resources for Labs



AACC has gathered essential information and resources to help laboratories implement and expand coronavirus disease 2019 (COVID-19) testing, including the latest research form its journals and free education programs for laboratory medicine professionals.

Quick Links

COVID-19 Research

SARS-CoV-2 serologic immune response in exogenously immunosuppressed patients

Read the Journal of Applied Laboratory Medicine Article External Link

Assessment of multiplex digital droplet RT-PCR as a diagnostic tool for SARS-CoV-2 detection in nasopharyngeal swabs and saliva samples

Read the Clinical Chemistry Article External Link

Implementation of Reverse Transcriptase Polymerase Chain Reaction Testing for Severe Acute Respiratory Syndrome Coronavirus-2 Under the U.S. Food and Drug Administration Emergency Use Authorization

Read the Clinical Chemistry Article External Link

Accuracy in measuring racial disparities during the COVID-19 pandemic needs improvement

Read the Journal of Applied Laboratory Medicine Article External Link

What is the impact of COVID-19 pandemic upon therapeutics of opioids crisis and the strategy to mitigate these effects?

View the Scientific Short Article External Link

What are the clinical laboratory result abnormalities in patients hospitalized with COVID-19?

View the Scientific Short Article External Link

COVID-19 Pandemic Planning: Simulation models to predict biochemistry test capacity for patient surges

Read the Journal of Applied Laboratory Medicine Article External Link

Is there a role for the clinical chemistry laboratory in the management of patients with COVID-19?

View the Scientific Short Article External Link

DNA cross-reactivity of the CDC-specified SARS-COV-2 specimen control leads to potential for false negatives and underreporting of viral infection

Read the Clinical Chemistry Article External Link

Analytical and Clinical Analysis of Two Automated Anti-SARS-CoV-2 Immunoassays in Pre-pandemic and Pandemic Patient Populations

Read the Journal of Applied Laboratory Medicine Article External Link

Side-by-Side Comparison of Three Fully Automated SARS-CoV-2 Antibody Assays with a Focus on Specificity

Read the Clinical Chemistry Article External Link

Swab-free transport as an optimized pre-analytical workflow for SARS-COV-2 amplification

Read the Journal of Applied Laboratory Medicine Article External Link

Mass Spectrometry for COVID-19

Read the Clinical Chemistry Article External Link

SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission

Read the Clinical Chemistry Article External Link

Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric reverse-transcription loop-mediated isothermal amplification 

Read the Clinical Chemistry Article External Link

Correlation of SARS-CoV-2 neutralizing antibodies to an automated chemiluminescent serological immunoassay

Read the Journal of Applied Laboratory Medicine Article External Link

Comparison of two automated immunoassays for the detection of SARS-CoV-2 nucleocapsid antibodies

Read the Journal of Applied Laboratory Medicine Article External Link

Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease

Read the Clinical Chemistry Article External Link

Cautionary Note on Contamination of Reagents Used for Molecular Detection of SARS-CoV-2 

Read the Clinical Chemistry Article External Link

Association between SARS-CoV-2 Neutralizing Antibodies and Commercial Serological Assays

Read the Clinical Chemistry Article External Link

Evaluation of Orthogonal Testing Algorithm for Detection of SARS-CoV-2 IgG Antibodies

Read the Clinical Chemistry Article External Link

Evaluation of Three Commercial Automated Assays for the Detection of Anti-SARS-CoV-2 Antibodies

Read the Clinical Chemistry Article External Link

AACC Survey Finds That Labs Still Do Not Have Supplies for COVID-19 Testing

View the Survey Results

Routine laboratory blood tests predict SARS-CoV-2 infection using machine learning 

Read the Clinical Chemistry Article External Link

Out of the Darkness-Into the Light: Value of SARS-CoV-2 Antibody Testing in Populations to Benefit Public Health and in Individuals for Peace of Mind

Read the Journal of Applied Laboratory Medicine Article External Link

Screening the general population for SARS CoV-2 virus and COVID-19 antibodies: A counter-argument

Read the Journal of Applied Laboratory Medicine Article External Link

Hydroxychloroquine interference in common biochemistry laboratory assays

Read the Journal of Applied Laboratory Medicine Article External Link

What to expect from antibody assays of SARS-CoV-2

Read the Journal of Applied Laboratory Medicine Article External Link

Laboratory tests and outcome for patients with COVID-19: A systematic review and meta-analysis

Read the Journal of Applied Laboratory Medicine Article External Link

Antibody Profiles in Mild and Severe Cases of COVID-19

Read the Clinical Chemistry Article External Link

Clinical Validation of a SARS-CoV-2 Real-Time Reverse Transcription PCR Assay Targeting the Nucleocapsid Gene

Read the Journal of Applied Laboratory Medicine Article External Link

Clinical Performance of the Roche SARS-CoV-2 Serologic Assay

Read the Clinical Chemistry Article External Link

Clinical performance of the Elecsys electrochemiluminescent immunoassay for the detection of SARS-CoV-2 total antibodies

Read the Clinical Chemistry Article External Link

AACC Issues Recommendations on the Use of COVID-19 Antibody Tests

Read the Statement

Molecular and Serological Assays for SARS-CoV-2: Insights from Genome and Clinical Characteristics

Read the Clinical Chemistry Article External Link

Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19

Read the Journal of Applied Laboratory Medicine Article External Link

Clinical Performance of Two SARS-CoV-2 Serologic Assays

Read the Clinical Chemistry Article External Link

Rapid detection of SARS-CoV-2 by low volume real-time single tube reverse transcription recombinase polymerase amplification using an exo probe with an internally linked quencher

Read the Clinical Chemistry Article External Link 

Metagenomic analysis reveals clinical SARS-CoV-2 infection and bacterial or viral superinfection and colonization

Read the Clinical Chemistry Article External Link

Modeling SARS-CoV-2 positivity using laboratory data: timing is everything

Read the Clinical Chemistry Article External Link

Unleashing the Power of Laboratory Developed Tests: Closing gaps in COVID diagnosis and beyond

Read the Journal of Applied Laboratory Medicine Article External Link

Selecting a SARS-CoV-2/COVID molecular testing method for your laboratory

Read the Journal of Applied Laboratory Medicine Article External Link

Preparedness and Rapid Implementation of External Quality Assessment Helped Quickly Increase COVID-19 Testing Capacity in the Republic of Korea

Read the Clinical Chemistry Article External Link

Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-mediated Isothermal Amplification Diagnostic Platform

Read the Clinical Chemistry Article External Link

Limits of Detection of Six Approved RT–PCR Kits for SARS-CoV-2

Read the Clinical Chemistry Article External Link

COVID-19 in Pediatrics: A Laboratory Perspective

Read the Journal of Applied Laboratory Medicine Article External Link

A Laboratory Risk Assessment during the COVID-19 Pandemic

Read the Journal of Applied Laboratory Medicine Article External Link

Heat Inactivation in Laboratories Might Contribute to False Results for SARS-CoV-2 Tests

Read the Clinical Chemistry Article External Link

What Diagnostic Tests Are Available to Help Combat COVID-19?

View the Scientific Short Article External Link

The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception

Read the Clinical Chemistry Q&A External Link

Emergence of Novel Coronavirus Disease and the Importance of Diagnostic Testing

Read the Clinical Chemistry Opinion External Link

Two New Rapid Coronavirus Tests Could Play a Key Role in Efforts to Contain Growing Epidemic

Read the Clinical Chemistry Study External Link

Racing Towards the Development of 2019 Novel Coronavirus Diagnostics

Read the Clinical Chemistry Editorial External Link


COVID-19 Education

SARS-CoV-2 2021: A Panel Discussion on Impact of SARS-CoV-2 and Near-Future Considerations

As we approach the end of year, we need to look forward. The unique challenges of SARS-CoV-2 and SARS-CoV-2 testing this past year will provide some insight into what we need to think about going into a new year.

View the Webinar

On the Horizon of SARS-CoV-2 Testing: Improving Testing, Technologies, and Collaborations Across the Healthcare Team

How are we staying ahead of the coronavirus? As the world looks ahead, Drs. Luning and Wang will discuss the information that is or will be available to help the laboratory medicine and broader healthcare community that will help combat the unique challenges of SARS-CoV-2 spread and testing. 

View the Webinar

Putting SARS-CoV-2 Testing into Practice: Overcoming the Day-to-Day Challenges of Laboratorians and Infectious Disease Clinicians

Since this pandemic has begun, the healthcare community had to face several challenges. Understand how to overcome the operational challenges of supply chain issues, managing testing materials, test validation protocols, reimbursement, and staffing. Hear perspectives a laboratory professional and infectious disease physician to implement and/or improve SARS-CoV-2 testing.

View the Webinar

SARS-CoV-2 Testing: Where We are Today

Going beyond the basics, Dr. Pettengill will discuss the latest information on how SARS-CoV-2 has evolved and spread into the pandemic we have today. Discussion will also focus on the advantages and limitations of testing methods including PCR, serology, and antigen testing as well as testing platforms.

View the Webinar

SARS-CoV-2 Testing: Selecting the Right Test for the Right Person

Implementing the correct test at the appropriate time is crucial for SARS-CoV-2 diagnosis. However, the frequent emergence of new assays, changes to regulations, and constantly revising guidelines may cause considerable confusion among laboratorians. This live webinar will teach you how to navigate guidelines and regulations to implement appropriate SARS-CoV-2 testing.

View the Webinar

Current State of COVID-19 Point-of-Care Testing: Blood Gases, Biomarkers, and Future Directions

Dr. Nam K. Tran will provide an overview of common chemistry and point-of-care tests employed when treating COVID-19 patients. These include blood gas analysis and biomarkers of infection and injury. He will also discuss future directions such as the use of machine learning and mass spectrophotometric methods.

View the Webinar

SARS CoV-2: Rising to the testing challenge in the United States

In this webinar, Dr. Steven Cagas and Dr. M. Laura Parnas explain the CoV family of viruses, the unique features of SARS-CoV-2 and COVID-19, the current outbreak epidemiology, as well as current biomarkers, serological assays, and potential therapies for COVID-19.

View the Webinar

The Role of Laboratory Diagnostics in SARS-CoV-2 Infection and Related Comorbidities: Experiences and Population Management Strategies from Highly Affected Regions of China and Italy

Professor Mario Plebani and Professor Shu Kui Wang give perspectives from Italy and China on how laboratory medicine can efficiently contribute patient care during the COVID-19 pandemic.

View the Webinar

Free Course on COVID-19 from AACC Learning Lab

AACC developed this content with leading scientists as part of AACC Learning Lab on NEJM Knowledge+. The free course covers COVID-19 transmission, complications, diagnosis, and more.

View the Course External Link

Pearls of Laboratory Medicine: Coronavirus Disease 2019 (COVID-2019)

In this video, Giuseppe Lippi of the University Hospital of Verona, Italy, provides an overview of Coronavirus Disease 2019 (COVID-19).

Watch the English Video External Link

Watch the Chinese Video External Link

Clinical Chemistry Podcast: Why Clinical Labs Are Essential to Containing COVID-19

Dr. Matthew Binnicker gives an update on the coronavirus outbreak and discusses what is needed to bring this global epidemic under control. This podcast is in English and Chinese.

Listen to the Podcast

Clinical Chemistry Podcast: Molecular Diagnosis of a Novel Coronavirus

Dr. Leo Poon of the University of Hong Kong gives expert insight into the 2019 novel coronavirus, and discusses the new molecular diagnostic assays his team has developed to detect and quantify this virus. This podcast is in English and Chinese.

Listen to the Podcast


Key Resources

Food and Drug Administration

Contact FDA: If you are trying to obtain an EUA for a COVID-19 test, send all comments and questions to CDRH-EUA-Templates@fda.hhs.gov.

You can also report issues with FDA-authorized COVID-19 tests or related materials by calling 1-888-INFO-FDA.

Other FDA resources:

Centers for Disease Control and Prevention

National Institutes of Health

In response to questions about turnaround time for laboratories to acquire positive control RNA, AACC has confirmed that the NIH Biodefense and Emerging Infections Research Resources Repository is prioritizing SARS-CoV-2 and anticipates a 12-72 hour turnaround.

Centers for Medicare and Medicaid Services

 

Get to Know AACC

Sign up to receive AACC product announcements, event information, and industry news.