DOI: 10.1373/clinchem.2014.227165


A 77-year-old woman with a history of excessive bleeding and questionable diagnosis of von Willebrand disease (VWD)5 presented for a presurgical evaluation. Her daughter and grandson also had a history of a bleeding disorder. Bleeding events reported by the patient and her family members included easy bruising, postsurgical bleeding and hematoma formation requiring intervention with drainage and blood products, and excessive bleeding during childbirth.