American Association for Clinical Chemistry
Better health through laboratory medicine
NACB - Scientific Shorts
NACB - Scientific Shorts (formerly NACB Blog)
By Dustin Bunch
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Matrix effects are regarded as the Achilles’ heel of clinical liquid chromatography tandem mass spectrometry (LC-MS/MS). Our laboratory has been developing clinical LC-MS/MS assays since 2006. To aid with assay validation, a protocol was established that included a serious investigation of matrix e...(Read More)
By Victoria Bevilacqua and Khosrow Adeli
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In order to appropriately interpret laboratory test results in a clinical setting, it is crucial that reliable reference intervals be available.  Establishing reference intervals in any population is a difficult and involved process; however, it is especially challenging in a pediatric population. ...(Read More)
By Julia C. Drees, Ph.D., DABCC
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​An endocrinologist contacted our laboratory to report a patient with discordant TSH results: undetectable TSH by our routine assay, the Siemens ADVIA Centaur TSH3-UL, and normal TSH by an alternate TSH assay, the Abbott Architect. The clinical picture of the patient matched the normal results. We ...(Read More)
By William E. Winter, MD; Roger L. Bertholf, Ph.D.
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​Challenge: I was recently asked what medical concerns exist for people with autoimmune diabetes [either type 1 diabetes or latent autoimmune diseases of adulthood (LADA)] that are not shared by people with type 2 diabetes. Certainly for all people with diabetes of any kind, attempting to achieve...(Read More)
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