Slides and Handouts

AACC/MSSS: Mass Spectrometry and Separation Sciences for Laboratory Medicine
5th Annual Conference

October 1-2, 2015 * Doubletree Hotel * Chicago, IL

Organizing Committee: Steven W. Cotten, PhD (Ohio State University Wexner Medical Center); R. Brent Dixon, PhD (Physician’s Choice Laboratory Services); Saeed A. Jortani, PhD (University of Louisville); Steven H. Wong, PhD (program chair, Wake Forest University School of Medicine); Victoria Y. Zhang, PhD (University of Rochester Medical Center); Yusheng Zhu, PhD (Medical University of South Carolina)

Developed in cooperation with AACC’s Mass Spectrometry and Separation Sciences Division

Funding for this program has been provided by: Agilent Technologies, Inc.; Cerilliant Corporation; Chromsystems; Hamilton Company; Indigo BioAutomation; IONICS Mass Spectrometry; Orochem Technologies; SCIEX Diagnostics; Thermo Scientific; UTAK Laboratories; and Waters Corporation.

Conference Program
Roster
Speaker Biographies & Disclosures
Supporter Information
AACC LDT Position Statement
Continuing Education
Participant Wish List of Mass Spec Assays

DAY 1
Thursday, October 1

SESSION I: SCOPE OF MASS SPEC TESTING FOR LABORATORY MEDICINE/PATHOLOGY

KEYNOTE ADDRESS
High Resolution Mass Spectrometry for Laboratory Medicine – Current Status and Perspectives in TDM-Tox
Professor Dr. Hans Maurer
Saarland University (Homburg, Germany)
(Slides)     (Handout)

Panel Discussion: Navigating Development and Implementation of Mass Spec-based LDTs
Saeed A. Jortani, PhD – Moderator
University of Louisville (Louisville, KY)

Henry Rodriguez, PhD, MBA
National Institutes of Health/National Cancer Institute (Bethesda, MD)

Alberto Gutierrez, PhD
U.S. Food and Drug Administration (Silver Spring, MD)

Steven J. Soldin, PhD
National Institutes of Health Clinical Center (Bethesda, MD)

Charles Root, PhD
CodeMap, LLC (Schaumberg, IL)

SESSION II: ESSENTIAL CONCEPTS IN CLINICAL MASS SPEC

Common Mistakes in LC-MS/MS Assay Development - What They Are and How to Avoid Them
Daniel T. Holmes, MD
St. Paul’s Hospital Providence Health Care (Vancouver, British Columbia)
(Slides)     (Handout)

Sample Preparation – A Practical Approach for Robust Analyses
R. Brent Dixon, PhD
Physicians’ Choice Laboratory Services (Rock Hill, SC)
(Slides)     (Handout)

Bringing Mass Spectrometry to Clinical Practices: Finance, Personnel and Interface Considerations
Victoria Y. Zhang, PhD
University of Rochester Medical Center (Rochester, NY)
(Slides)     (Handout)

Method Development and Validation for Certification in Accordance with CLSI C62-A and CAP Guidelines
Steven W. Cotten, PhD
The Ohio State University Wexner Medical Center (Columbus, OH)
(Slides)     (Handout)

Antifungals, TDM, and DAU Chiral Analysis by LC-MS/MS
Steven H. Wong, PhD
Wake Forest University School of Medicine (Winston-Salem, NC)
(Slides)     (Handout)

Complementary Role of GC/MS in the Clinical Laboratory and Beyond
Uttam Garg, PhD
Children's Mercy Hospitals and Clinics (Kansas City, MO)
(Slides)     (Handout)

SESSION III: INDUSTRY PERSPECTIVES

LC-MS/MS Development for the Clinical Lab – The SCIEX Perspective
Matthew Clabaugh
SCIEX Diagnostics (Framingham, MA)

(Slides) (Handout)

Agilent Mass Spectrometry: Go Faster

Mike Scott
Agilent Technologies (Santa Clara, CA)

(Slides) (Handout)

Big Data and Intelligent Algorithms in Diagnostic Testing

Randall Julian, PhD
Indigo BioAutomation (Indianapolis, IN)

(Slides) (Handout)

Opportunities in Clinical Mass Spec
Sherry Gregory
Thermo Fisher Scientific (West Palm Beach, FL)

(Slides) (Handout)

SESSION IV: Open Forum: “Clinics in Mass Spec Analyses”

  • Tips for practical day-to-day operation of mass spec tools
  • Audience questions

End of Day 1

DAY 2
Friday, October 2

SESSION V: Translating Mass Spectrometry Tools to Clinical Practice

PLENARY LECTURE
The Role of Assay Specificity in Improving Diagnosis and Treatment of Endocrine Disorders
Steven J. Soldin, PhD
National Institutes of Health Clinical Center (Bethesda, MD)
(Slides)     (Handout)

Measurement of Water Soluble Vitamins by UPLC-MS/MS
Yusheng Zhu, PhD
Medical University of South Carolina (Charleston, SC)
(Slides)     (Handout)

PLENARY LECTURE
Metabolomic Analysis for Newborn Screening and Diagnosis of Metabolic Disorders
Michael J. Bennett, PhD
Children’s Hospital of Philadelphia (Philadelphia, PA)
(Slides)     (Handout)

Advanced Pain Management – Pharmacogenomics Data to Complement Oral Fluid Compliance Testing
R. Brent Dixon, PhD
Physicians’ Choice Laboratory Services (Rock Hill, SC)
(Slides)     (Handout)

The Future of Reimbursement for Mass Spec-based LDTs
Charles Root, PhD
CodeMap, LLC (Schaumberg, IL)
(Slides)     (Handout)

SESSION VI: “NEXT GENERATION” MASS SPEC ANALYSES FOR 2020

SPECIAL LECTURE
Emerging Mass Spec Applications in Anatomic Pathology: Tissue Imaging
Richard M. Caprioli, PhD
Vanderbilt University (Nashville, TN)
(Slides)     (Handout)

Translating “-Omics” Biomarkers from Bench to Bedside
Victoria Y. Zhang, PhD
University of Rochester Medical Center (Rochester, NY)
(Slides)     (Handout)

Linking Massive DNA Sequencing with Mass Spec Proteomics for Advancing Cancer Research and Precision Medicine
Henry Rodriguez, PhD, MBA
National Institutes of Health/National Cancer Institute (Bethesda, MD)
(Slides)     (Handout)

Massively Multiplexed Cellular Analysis
Sean C. Bendall, PhD
Stanford University School of Medicine (Stanford, CA)
(Slides)     (Handout)

Panel Discussion
Envisioning “Next Generation” Clinical Mass Spec-based Diagnostics in 2020
Steven H. Wong, PhD– Moderator
Wake Forest University School of Medicine (Winston-Salem, NC)

Professor Dr. Hans Maurer
Saarland University (Homburg, Germany)

Sean C. Bendall, PhD
Stanford University School of Medicine (Stanford, CA)

Angella Charnot-Katsikas, MD
The University of Chicago (Chicago, IL)

Henry Rodriguez, PhD, MBA
National Institutes of Health/National Cancer Institute (Bethesda, MD)

End of Conference