AACC uses Cookies to ensure the best website experience. Continuing without changing Cookie settings assumes you consent to our use of cookies on this device. You can change these settings at any time, but that may impair functionality on our websites. Review our cookie and privacy policy

Laboratory and Clinical Perspectives: Understanding Findings of Sex-specific 99th Percentile URLs for High-sensitivity Cardiac Troponin Assays Derived from Universal Sample Bank

  • Credit:1.25 ACCENT Credits
  • Duration: 1 Hour 15 Minutes
  • Date:JUN.17.2020 1:00 PM

Price: $0.00

Member Price: $0.00


Selection of healthy reference populations and definition of exclusion criteria for deriving 99th percentiles for high-sensitivity cardiac troponin assays (hs-cTn) used in clinical practice and research vary considerably. Dr. Fred S. Apple and Dr. W. Frank Peacock discuss the following Universal Sample Bank findings and their clinical implications: 

  • Sex-specific 99th percentiles varied according to the statistical method and hs-cTn assay used
  • Not all assays provided measurable concentrations for women to qualify as hs assays
  • Surrogate exclusion criteria used to define normality tended to lower 99th percentiles. 

Participants will learn that the decision concentrations used can affect diagnostics, risk-outcome assessments, and analytical characteristics.


  • Identify sex-specific 99th percentiles variations according to the statistical method and hs-cTn assay used.
  • Describe why not all assays provided measurable concentrations for women to qualify as hs assays.
  • Summarize how and when surrogate exclusion criteria should be used to define normality.


Dr. Fred Apple Fred S. Apple, Ph.D. DABCC, FACSM (current)
Co-Medical Director, Clinical and Forensic Toxicology Laboratory, Hennepin Healthcare/Hennepin County Medical Center
Professor, Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine
Minneapolis, Minnesota

Dr. W. Frank PeacockW. Frank Peacock, MD, FACEP, FACC, FESC
Professor, Vice Chair for Research
Henry JN Taub Department of Emergency Medicine
Baylor College of Medicine
Houston, Texas

This activity is approved for 1.25 ACCENT® continuing education credits. Activity ID# 2000. This activity was planned in accordance with ACCENT® Standards and Policies.


siemens logo

AACC's Universal Sample Bank Click to learn more