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Certificate Program

Introductory Liquid Chromatography Mass Spectrometry for the Clinical Laboratory Certificate Program

  • Credit: 12.0 ACCENT
  • Level: Beginner

Price: $550.00

Member Price: $275.00

Rating: Member Average


This ten-course program was developed with clinical laboratory professionals in mind, particularly technologists who wish to be introduced to the principles, theory and inner workings of liquid chromatography mass spectrometry (LC-MS/MS) for laboratory analyses, as well as directors or supervisors who are considering bringing mass spectrometry technology to their laboratory and would like a primer course to the technology and its applications. The content of this program is at the basic level and yet covers the essential aspects of LC-MS/MS system and its applications in laboratory medicine. It would most benefit learners who have limited exposure to the technology through prior training or use or those who have prior training in the technology and would like to gain understanding of the clinical aspects of LC-MS/MS.

For an introduction about this new program please view this preview presentation by the Program Chair.

The program is composed of ten courses, listed below. Each course can be completed online in 1-3 hours and contains a lecture, reference materials and a quiz. Some include a required reading and practical exercises. Communicate questions or comments using the program discussion board.


  1. Why MS and its Applications
    • Learning Objectives: List the major clinical applications of mass spectrometry in clinical practices and describe the limitations and advantages of mass spectrometry
    • Speaker: Yusheng Zhu, PhD, DABCC FACB, Medical University of South Carolina, Charleston, SC

  2. Basic Laboratory Techniques
    • Learning Objectives: Understand the differences between gravimetric and volumetric measurement, and learn how to apply good measurement practices
    • Speaker: Judith Stone, PhD, DABCC, MT (ASCP), University of California-San Diego, San Diego, CA

  3. MS-Grade Reagents and Internal Calibrators
    • Learning Objectives: Review appropriate selection and production of reagents and standard materials
    • Speaker: Frederick Strathmann, PhD, DABCC (CC, TC), ARUP Laboratories, Salt Lake City, UT

  4. Basic Calculations
    • Learning Objectives: Properly calculate unit conversions and dilutions, and implement QA monitoring for MS assays
    • Speaker: Steven Cotten, PhD, DABCC FACB, Ohio State Wexner Medical Center, Columbus, OH

  5. High Performance Liquid Chromatography Introduction
    • Learning Objectives: Understand the functions of HPLC system components and its basicseparation mechanisms
    • Speaker: Y. Victoria Zhang, PhD, DABCC, University of Rochester Medical Center, Rochester, NY

  6. Mass Spectrometry Introduction
    • Learning Objectives: Learn the components of a mass spectrometer, and applications for different scan modes and approaches for data analysis
    • Speaker: Kara Lynch, PhD, DABCC FACB, University of California-San Francisco, San Francisco, CA

  7. Introduction to Sample Preparation and Basic Techniques
    • Learning Objectives: Recognize and differentiate common sample preparation techniques, and evaluate the advantages and disadvantages of implementing manual vs. automated sample preparation protocols
    • Speaker: Lorin Bachmann, PhD, DABCC, Virginia Commonwealth University Health System, Richmond, VA

  8. Reporting Results
    • Learning Objectives: Determine the proper ways for numerical data reporting using calibration curves and the integrity of the results.
    • Speaker: Michael Wright, SEALS, Prince of Wales Hospital, Sydney, Australia

  9. Implementing Mass Spectrometry
    • Learning Objectives: Explain what mass spectrometry specifications are important to consider when selecting an instrument, and the financial considerations for purchasing a mass spectrometry system
    • Speaker: Deborah French, PhD, DABCC, University of California-San Francisco, San Francisco, CA

  10. Overall Training
    • Learning Objectives: Describe training plan components need to meet guidance and regulatory standards, and be able to design essential tools to document training and competency assessment for a clinical mass spectrometry laboratory
    • Speakers: Shannon Haymond, PhD, DABCC FACB, and Faye Vicente, C(ASCP)CM, Lurie Children’s Hospital, Chicago, IL

Developed with AACC’s Mass Spectrometry and Separation Sciences Division.

Launch Year: 2016
Course Number: 12427

Supported By

Developed in cooperation with AACC’s Mass Spectrometry and Separation Sciences Division.