Issue

An antisense oligonucleotide (ASO) therapy that slowed progression of a fatal genetic disease in one young patient is pushing the boundaries of personalized medicine. While this case and others signal hope for tailoring therapies of rare genetic disorders, “N-of-1” single patient trials pose some ethical questions about accessibility, cost, and…

Clinicians rely on fourth-generation antigen/antibody (Ag/Ab) assays with an HIV-1/HIV-2 antibody differentiation follow-up test to diagnose HIV, a formula that can yield indeterminate results, leading to confusion and anxiety among physicians and patients, according to two infectious diseases specialists with extensive experience in diagnosing and treating HIV. HIV-1 RNA tests…

AACC voting members have passed three proposed changes to the association’s bylaws as enumerated by AACC Secretary Anthony Killeen, MD, PhD, at the 2019 Annual Scientific Meeting and in subsequent emails. During the voting period, September 1, 2019 to September 30, 2019, all three proposed changes were approved by more…

Driven by concerns about worldwide overuse of empiric therapies for multidrug-resistant pathogens, updated guidelines on community-acquired pneumonia (CAP) call for abandoning the broad category of healthcare-associated pneumonia and suggest more targeted pathways for sputum and blood cultures.

Though they vary somewhat on testing intervals and protocols, many guidelines on colorectal cancer (CRC) recommend 50 as the age to begin screening, given that risk for disease rises to 1-2% over the next 15 years at the half century mark. New guidelines in BMJ, however, challenge this long-held view.…