A 55-year-old man was admitted for impaired health status and lower back pains. Analysis of serum proteins by capillary zone electrophoresis (CZE) was performed on a Capillarys Protein(e) 6. The β1-globulin fraction showed a peak suggestive of the presence of a monoclonal component (Fig. 1A, dashed arrow). However, subsequent serum protein immunotyping (Capillarys Immunotyping) failed to demonstrate a monoclonal protein.

Fig. 1. CZE electropherograms of the patient's serum (A) and a reference sample (B).


    1. What type of detection does CZE use?
    2. What can cause interferences with this method?
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