The random urine sample shown in Fig. 1 was collected from a 43-year-old woman with systemic lupus erythematosus. A routine urinalysis (Aution Max AX-4280; Iris Diagnostics) revealed no remarkable findings and, specifically, was negative for protein. The corresponding urine protein concentration, however, was 448 mg/dL (reference interval, ≤12 mg/dL) as measured with a turbidimetric assay (Cobas c701; Roche Diagnostics). Protein concentrations in urine samples previously collected from this patient were undetectable.
- What is responsible for the unique appearance of this urine sample?
- Why did the substance interfere with testing on one platform but not the other?
- What precautions should be taken to prevent this interference in urine testing?
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