A urine sample submitted for a urinary calcium-to-creatinine ratio was visually clear but deep orange in color (Fig. 1, left). Acidification of the sample to pH <2.0 with HCl prior to analysis produced a color change in the sample from orange to deep red (Fig. 1, right). The 16-year-old female patient had a history of polycystic ovarian syndrome, oligomenorrhea, and vitamin D deficiency and a suspected urinary tract infection.
- What could have contributed to the peculiar color change phenomenon of this patient's urine sample?
- What phenomenon in this urine sample differentiates it from the other causes of similarly colored urine?
- Is this sample suitable for calcium (o-cresolphthalein) and creatinine (Jaffe) analysis?
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