Medical "Big Data" describes the massive data sets generated as a result of the genomic, proteomic and metabolomic revolutions. Such data sets are becoming employed across the entire spectrum of our laboratory activities. While these data sets will become extraordinarily useful, a fundamental concept embodied in "Big Data" serves to warn investigators that data queries must be very smart to derive correct conclusions; with so much data, biased queries could lead to incorrect conclusions. There is a new science required to interpret large data sets. Learn more from a world expert on this topic.