There is an increasingly wide variety of anticoagulants and antiplatelet agents available for clinical use. These drugs are among the most prescribed in the U.S. Some of these agents have a narrow therapeutic window, and others do not have any agent to reverse the anticoagulant or antiplatelet effect. Therefore, there is a need to determine if the dosage is correct and if more than one agent is in circulation. This presentation will describe the antiplatelet agents and anticoagulants in use, including newer agents. Faculty will discuss the actions and indications of each drug and will provide a more detailed description of options for monitoring the concentration and/or effects to ensure optimal patient outcome and reduce adverse drug events.