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This lecture will provide an overview of the sequencing process done in clinical laboratories with commonly used NGS instrumentation, and the bioinformatics resources used for analysis of massively parallel cyclic assays. There will be a discussion of common issues such as validation in somatic cancer panels, challenges to interpretation of test results posed by small sample sizes, as well as tumor heterogeneity, treatment resistance, and the question of selecting intratumor samples versus metastases. A Question and Answer session with the speaker will follow.
After participating in this webinar, you should be able to:
- Discuss the history of next generation sequencing in brief, the different types of molecular diagnostic instruments used for sequencing, and the basics of the DNA sequencing process using the most common platforms in clinical practice, the Ion Torrent and Illumina.
- Become familiar with guidelines and database resources for validation of molecular assays, as well as with the determinants that can affect which molecular technology is brought into a lab.
- Identify instances where test interpretation requires the additional support of literature and peer-reviewed evidence on clinical utility, and the clinical judgement of your lab team.
Lab managers and technologists who are involved in molecular testing, and laboratory directors who wish to bring molecular testing into the lab.
Andrea Ferreira-Gonzalez, PhD
Chair of the Division of Molecular Diagnostics in the Department of Pathology
Director of the Molecular Diagnostics Laboratory
Virginia Commonwealth University Health System, Richmond, VA