is a statistics program dedicated to the field of clinical biochemistry. The main areas covered are method evaluation and comparison, estimation of reference intervals, and diagnostic test evaluation, inclusive ROC plots. Additionally, general statistical routines are available for description and comparison of data. Modern computerized statistical procedures are included for estimation of standard errors, e.g. the jackknife and bootstrap principles.
The program contains procedures for method evaluation: estimation of detection limit (incl. CLSI EP17 procedure), within- and between-run precision, precision profile, and linearity (incl. CLSI EP6 linearity procedure). The following method comparison procedures are available: Bland-Altman plot, ordinary and weighted least-squares regression analysis, Deming, and weighted Deming regression analysis for proportional measurement errors. Polynomial regression is also offered. Parametric and non-parametric reference interval estimation by recommended IFCC procedures are included, and, additionally, more recently developed efficient procedures based on the bootstrap principle.
The statistical routines automatically include data validation procedures such as tests for linearity in the case of regression analysis and generally tests for outliers. Standard errors of estimates and/or confidence intervals are provided throughout, which can be used for evaluation of measurement uncertainty in appropriate contexts.
Data output and graphics can be printed, copied to the clipboard, or exported as files. A short User's Guide, a Tutorial, on-line Help, and a detailed Reference Manual (60 pages, pdf-document) are available in electronic form.
Please note that the program requires the period as a decimal separator in numbers, i.e. the period should be selected as the decimal separator for the Windows operating system (default in the US/English setup).
Further information and a demo version with sample size restriction are available from the website