Immunodiagnostics and Patient Safety

Immunodiagnostics and Patient Safety
  • Copyright:2011
  • ISBN:9783110249477
  • Pages:162

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Today, most immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity, and a short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on the frequency of occurrence of false-positive or false-negative results, which, if unrecognized, may lead to patient misdiagnosis, unnecessary treatment, or even unnecessary surgery. Deep knowledge of the basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies), and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce, and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient care and patient safety.