A new golden age has dawned in the medical laboratory. It comes at a time of great medical and societal challenges. It is also a time of unparalleled opportunities in genomics, proteomics, and molecular medicine. New techniques allow the clinical laboratory to meet these challenges and opportunities, even as the nature of the laboratory evolves. The papers collected here from Clinical Chemistry, along with the updates provided by their authors, can be read as a review of recent developments, or as a tool for catching up with the field. Either way, the book provides signposts for a new era in clinical chemistry and laboratory medicine. A casual reader, dipping into the book at random, will be rewarded with insights into current activities and glimpses of the future.