The investigation of liver disease constitutes a significant proportion of the workload of the clinical laboratory, spanning all disciplines. This book covers all aspects of the investigation of liver disease from initial evaluation of the patient to those tests that define a specific diagnosis. The first two chapters provide an introduction to the pathophysiology of liver disease and its effect on standard biochemical and hematological tests. Subsequent chapters include aspects of autoimmume liver diseases and the use of autoantibody tests to differentiate between autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis; inherited metabolic conditions and the advances in molecular techniques that have greatly improved the diagnostic power of laboratory diagnosis; and the laboratory assessment of patients prior to liver transplantation, including guidelines for immunosuppressive drug monitoring post-transplant. The pathophysiology of drug-induced liver damage is also discussed and details given of drugs for which the relationship to liver disease is well established.