Samples from patients with malignancy form a significant part of the workload of most hospital laboratories. Molecular biological techniques have opened up new areas of research, and applications are beginning to appear in clinical laboratories. This book goes beyond the laboratory aspects to consider the nature, behavior, and management of malignancy. An outline of the genetic changes that lead to the development of a tumor and influence its behavior is followed by a review of the non-specific biochemical abnormalities occurring in patients with cancer and their place in diagnosis and management. The chapters on tumor markers examine the nature of tumor markers, their role and limitations in diagnosis, monitoring, and prognosis, and the main cancers and their relevant tumor markers. Other chapters cover paraneoplastic syndromes, the treatments of cancer and their related problems, the mechanisms of action of chemotherapeutic drugs, and the biochemical abnormalities that may result from chemotherapy.