A 30-year-old African American man with sickle cell disease presented with diffuse joint pain, shortness of breath, nonproductive cough, and chest pain. Chest x-ray and computed tomography scan revealed cavitary lesions in the lungs. In addition, transthoracic echocardiogram showed moderate tricuspid value regurgitation and a 3 × 2.8 cm mass at the base of the posterior tricuspid valve consistent with vegetation. Blood cultures were positive for viridans streptococci. The patient was diagnosed with right-sided infective endocarditis and started on intravenous (IV) antibiotics.