A 48-year-old woman presented for radio-iodine ablation therapy 3 months after undergoing a complete thyroidectomy performed for compressive goiter symptoms. The patient’s medical history included stage-3 follicular variant papillary thyroid cancer with no nodal involvement and no metastatic disease. A 6.5-cm papillary carcinoma had been identified and removed surgically. Despite this surgical treatment, 3 foci were detected by 125I uptake testing, a finding that prompted the use of therapeutic ablation.