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Toxicology Topic Track

These sessions examine the major trends impacting the field of toxicology, including the latest developments in cannabis testing, the use of mass spectrometry for drug screening, and the potential of oral fluid as a drug testing matrix.


Oral Abstract Session: What's New in Toxicology and Therapeutic Drug Monitoring 34101

AACC is dedicated to advancing the science and practice of laboratory medicine. A select group of members have reviewed the abstracts submitted for the AACC Annual Scientific Meeting. The Annual Meeting Organizing Committee has reviewed the abstracts in the area of Toxicology and Therapeutic Drug Monitoring and have chosen several of these authors to present their findings as oral presentations. Each 15 minute presentation will be followed by a 5 minute question-and-answer session.

Moderator: Donald LeGatt, PhD, FCACB, University of Alberta Hospital, Edmonton, Canada.

Oral Fluid in the Clinical Toxicology Laboratory: Ready for Prime Time? 74217

This session will present advantages and drawbacks on the utility of oral fluid as a drug testing matrix in a clinical laboratory. The potential for interpretation of oral fluid drug concentrations will be discussed.

Moderator: Christine Moore, PhD, DSc, DABCC, Immunalysis Corporation, Pomona, CA.

Speakers: Importance of Specimen Collection, Analytes, and Cutoffs, Christine Moore, PhD, DSc, DABCC, Immunalysis Corporation, Pomona, CA; Testing Oral Fluid in the Office: Advantages and Drawbacks, Gary Reisfield, MD, University of Florida, College of Medicine, Gainesville, FL; Comparison of Blood and Oral Fluid Drug Concentrations and Potential for Interpretation, Andrea Terrell, PhD, DABCC, American Institute of Toxicology, Indianapolis, IN.

*Brown Bag Session: Mass Spectrometry in the Clinical Lab: Applications for Emergency Toxicology 44103 (Repeats as 54203)

Speaker: Jennifer Colby, PhD, DABCC, Vanderbilt University, Nashville, TN.

*Brown Bag Session: Evaluation of Time-of-Flight High Resolution Mass Spectrometry for Broad Spectrum Drug Screening in Urine 44122 (Repeats as 54222)

Speaker: Imir Metushi, University of California San Diego-CALM, San Diego, CA.


Plenary Session: The Great Cannabis Experiment: Medical Miracle? Harmless High? Civil Consequences? 15001

This lecture will explore recent developments in the science and use of cannabis, including effects of acute and chronic cannabis exposure, cannabis use and the impact on driving, measurement of cannabinoids in blood and oral fluid, as well as the detection of these compounds and their effects after sustained abstinence. Professor Huestis and her group conduct important research into the mechanisms of action of cannabinoid agonists and antagonists, the effects of in utero drug exposure, and the neurobiology and pharmacokinetics of novel psychoactive substances. Recently, Professor Huestis and colleagues documented that CB1-cannabinoid receptors are significantly down regulated in specific brain regions in chronic daily cannabis smokers, but these receptors significantly increased with sustained cannabis abstinence.

Speaker: Marilyn Huestis, PhD, National Institute on Drug Abuse, Baltimore, MD.

Marijuana from the Street to the Clinic: Medicalization, Legalization, and Unintended Consequences 35102

This session will provide a discussion of the impact of cannabis use in various populations. Particular attention will be paid to prenatal and perinatal use of marijuana, the impact of marijuana on neurodevelopment in different populations, and challenges for the clinical laboratory in the context of cannabis testing. Attendees will hear about these issues in the context of legalization of marijuana and its unintended consequences.

Speakers: Counseling Women about Prenatal Marijuana Use: Weeding through the Data, Torri Metz, MD, Denver Health Medical Center; The Great Marijuana Experiment, the Developing Adolescent Brain and Challenges for the Clinical Laboratory, Marilyn Huestis, PhD, University of Maryland School of Medicine.

*About Brown Bag sessions: These small discussion settings provide intimate exchanges between participants and experts. Expect lively conversation, dialogue, and debate, as well as Q&As. Attendance is limited to 10 participants. Advance registration and fees are required.