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King

2009 Award for Outstanding Contribution for a Publication in the International Journal Clinical Chemistry.

Dr. King is associate professor of biomedical engineering at Cornell University in Ithaca, N.Y. Trained as a chemical engineer, his research focuses on the receptor-mediated adhesion of circulating cells and the physical mechanisms of inflammation, thrombosis, and cancer metastasis. He is the inventor of “multiple adhesive dynamics,” a computational algorithm for the prediction of blood cell adhesion under flow. Dr. King has published more than 50 journal articles and two books, Principles of Cellular Engineering: Understanding the Biomolecular Interface and Heat Transfer and Fluid Flow in Minichannels and Microchannels. His award-winning article, “P-Selectin-Coated Microtube for Enrichment of CD34+ Hematopoietic Stem and Progenitor Cells from Human Bone Marrow,” describes a novel approach using adhesion proteins to isolate adult stem cells from bone marrow in a flow-based manner that mimics the initial steps of stem cell homing in the bone microvessels. The approach holds promise for the development of benchtop kits for research and diagnostic cell isolation, and could improve the efficiency of apheresis stem cell collection for bone marrow transplantation procedures. This study has led to other versions of the technology being applied to in vivo stem cell collection, isolation of mature hematopoietic cell types from bone marrow or peripheral blood, and isolation of viable circulating tumor cells from patient blood. The paper’s co-authors were Srivinas D. Narasipura, Joel C. Wojciechowski, Nichola Charles, and Jane L. Lieswald.