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Fred S. Apple, PhD

2009 Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research

Dr. Apple is medical director of clinical laboratories, clinical chemistry, toxicology, and point-of-care testing at Hennepin County Medical Center in Minneapolis and professor of laboratory medicine and pathology and of kinesiology at the University of Minnesota School of Medicine. He is also a forensic toxicology consultant for the Hennepin County medical examiner’s office. Dr. Apple’s research has centered in the areas of cardiac biomarkers in acute coronary syndrome and heart failure; fetal protein expression in injured skeletal muscle, specifically addressing the biochemistry of exercise; and postmortem redistribution of drugs. He has published more than 190 scientific papers. His research laboratory, the Cardiac Biomarkers Trials Lab at the Minneapolis Medical Research Foundation, is independently funded and works closely with the in vitro diagnostics industry in clinical and analytical studies of cardiac biomarkers. He served as a member of the AACC subcommittees for standardization of cardiac troponin-I and CK-MB as well as on the National Academy of Clinical Biochemistry committee to establish clinical and laboratory practice guidelines for the use of biomarkers for acute coronary syndromes and heart failure. He has served on several editorial boards, including those of Clinical Chemistry, Clinical Proteomics, and Critical Reviews in Clinical Laboratory Sciences. He is currently chair of the International Federation of Clinical Chemistry and Laboratory Medicine committee on the standardization of markers of cardiac damage and of the Institute of Medicine committee on qualification of biomarkers as surrogate endpoints of chronic disease risk.