The authors of March's Clinical Case Study provided us with three exclusive questions that will not appear in the published version of the Case. We'd love to hear your answers to these questions in the comments section.

1) What are the metabolites ofethylene glycol that lead to toxicity?

2) Why is propylene glycol (used in "safer" antifreezes) less toxic than ethylene glycol?

3) Why are pyridoxime (vitamin B6) and thiamine (vitamin B1) used in the treatment of ethylene glycol poisoning?


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