A 2012 paper in Nature by Fan et al. and a 2012 paper in Science Translational Medicine by Kitzman et al. describe the noninvasive determination of the entire fetal genome from maternal blood. What implications do you foresee arising from this discovery? How will this build on current clinical practices?

In the current issue of Clinical Chemistry, experts discussed the use of cell-free fetal DNA in maternal circulation for detection of chromosomal aneuploidies in this Q&A (free to access). We’d like to hear what you have to say about this topic.