2007 Oak Ridge Abstracts

Harnessing New Technology for Clinical Diagnostics

April 19 & 20, 2007

Hyatt Regency at Union Station

St. Louis, Missouri


2007 Oak Ridge Conference Abstract Titles

Abstract 5  

A novel technology platform for the ultrasensitive detection of cardiac troponin I (cTnI): Clinical utility in the emergency department.
Shipp G. Nanosphere, Inc., Northbrook, Ill.

 

Abstract 6  

Optically stimulated piezofilm detection—a novel, sensitive, non-separation assay designed for point-of-care applications.
Ross SA, Carter TJN. Vivacta Limited, Kent Science Park, UK.

 

Abstract 10

Positive identification of patient samples using polymorphic DNA sequences as internal markers: the barcode of the future?
Haliassos A1,2, Drakoulis N3.

1 Greek External Quality Assesment Scheme , Athens, Greece, 2Diamedica S.A., Athens, Greece,  and 3University of Athens, Athens, Greece.

 

Abstract 11

Multiplexing diagnosis of human infectious diseases.
Conant CG, McLaughlin S, Mollova ET, Patil V, Zhang M, Cameron D, Gilmanshin R. U.S.Genomics, Woburn, Mass.

 

Abstract 12

Inhibitor-resistant Forced Enzyme complementation based homogeneous immunoassay.
De Las Heras R, Li J, Fry S, McCourt J, Huang C, Arel E, Hazell S, Kachab E. Panbio Ltd., Brisbane, Australia.

 

Abstract 13

Application of forced enzyme complementation technology: The detection of IgG antibodies to Herpes Simplex Virus in a homogeneous immunoassay.
De Las Heras R, Li J, Fry S, McCourt J, Huang C, Arel E, Hazell S, Kachab E. Panbio Ltd, Brisbane, Australia.

 

Abstract 14

Isolation of viral RNA from infected mammalian cells on a disposable plastic microchip for low-cost, point-of-care diagnostics.
Bhattacharyya A1, Klapperich

CM1, 2. 1Department of Biomedical Engineering, Boston University, Boston, Mass., and 2Department of Manufacturing Engineering, Boston University, Boston, Mass.

 

Abstract 15

A lab-on-a-film chip (LOFC) microfluidic diagnostic device capable of quantitative electrochemical immuno-enzymatic assays.
Kim YH1, Park JH1, Nam H2, Choi MH2, Jung SH2. 1Nano-Ditech Corporation, Monmouth Junction, N.J., and 2i-Sens Corporation, Seoul, Korea.

 

Abstract 16

Detection of lung cancer patients with novel biomarker panels.
Li ZQ, Verch T, Allard WJ. Fujirebio Diagnostics, Inc., Malvern, Pa.

 

Abstract 17

Quantitative, reproducible, sensitive fluorescent lateral flow assays: Next generation performance based on appropriate design and manufacturing principles and a portable fluorescent reader system.
O’Farrell B. Diagnostic Consulting Network, Carlsbad, Calif.

 

Abstract 18

A handheld immunosensing device based on low-cost, self-contained microfluidic devices and ferromagnetic actuation .
Robillot C1, Fitzpatrick J1, Grimmer S1, Kettle B1, Dadic D2, Drese K2. 1Cleveland Biosensors Pty Ltd, Brisbane, Australia, and 2Institut f
ü r Mikrotechnik, Mainz, Germany.

 

Abstract 19

Determination of PSA and CRP using a reliable POCT system.
Maeda Y1, Kawaguchi T1, Nozue K2, Matsuda T 3, Komoda T 4. 1SEIKEN Co. Ltd, Tokyo, Japan, 2Bio Cyber Co. Ltd, Shizuoka, Japan, 3ASKA Special Laboratory Co. Ltd, Kanagawa, Japan, and 4Saitama Medical University, Saitama, Japan.

 

Abstract 21

A novel method for cell lysis for the rapid detection of intracellular protein using paramagnetic particles.
Sharif EA, McLeod JD, Luxton RW. University of the West of England, Bristol, UK.

 

Abstract 22

Development of a sensitive luminescence immunoassay (LIA) for glutamate in biological fluids.
Van Faassen HJR1, Meppelink GM1, Booltink E1, and Manz B1. 1Labor Diagnostika Nord, Nordhorn, Germany.

 

Abstract 23

The LiMA technology: Measurement of ATP on a NAT platform.
Banin S, Wilson S, Stanley C. ISEAO Technologies Ltd, London, UK.

 

Abstract 24

The use of antibody coated paramagnetic particles as a label for the rapid detection of PSA.
Sharif EA, Hawkins P, Kiely J, Luxton RW. University of the West of England, Bristol, UK.

 

Abstract 26

Robust horseradish peroxidase catalyzed chemiluminescence technology for microtiter plate based immuno-diagnostic assays.
Kumar A, Kalra B. Diagnostic Systems Laboratories-Beckman Coulter Inc., Webster, Texas.

 

Abstract 27

Lanthanide phosphate nanorods can be used as inorganic fluorescent label in cell biology research.
Chittaranjan P,  Resham B, Sujata P, Sujit B, Priyabrata M, Debabrata M. Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minn.

 

Abstract 28

A fully automated nucleic acid detection technology.
Nurmi J, Syrjälä A, Hagren V, von Lode P. Abacus Diagnostica Ltd., Turku, Finland.

 

Abstract 29  

Stabilization of dried PCR reagents.
Nurmi J, Hagren V, Syrjälä A, von Lode P.

Abacus Diagnostica Ltd., Turku, Finland.

 

Abstract 30  

Evaluation of automated calculation of mean blood glucose (MBG) values from a POCT instrument in correlation with glycated hemoglobin (HbA1c).
Makris K1, Spanou L1, Drakopoulos I1, Katritsis D2, Vlahou M1, Haliassos A3. 1Clinical Biochemistry Laboratory, K.A.T. General Hospital, Kiffisia, Greece, 2Cardiology Department, Athens Euroclinic, Athens, Greece, and 3Greek External Quality Assessment Scheme (GEQAS), Greece.

 

Abstract 31

Non-invasive monitoring of glucose and hemoglobin.
Ma'ayan L, Primack H, Weinstein A. OrSense Ltd., Nes-Ziona, Israel.

 

Abstract 32  

High magnetization magnetic beads for fast magnetic separation.
Fujii S, Nakabayashi T, Kaneko Y, Adachi M, Tokoro H. Hitachi Metals Ltd., Saitama, Japan.

 

Abstract 33  

A point-of care test design using sequential immunoassay for sensitive detection of specific IgE antibodies.
Nystrand M, Jonsson A, Holmquist S, Matsson P. Phadia AB, Uppsala, Sweden.

 

Abstract 34

Rapid (15 min) microfluidic microarray hybridization using target single-stranded DNA produced by selective digestion with Lambda exonuclease.
Boissinot K1*, Huletsky A1, Peytavi R1, Turcotte S1, Boissinot M1, Picard FJ1, Bergeron MG1. 1Centre de Recherche en Infectiologie, Université Laval, Québec City, Canada.

 

Abstract 35

The NIDS® technology: Nanomanipulation of bioactive molecules on particle surfaces enabling increased sensitivity, multiplexing and quantitation in rapid diagnostic tests.
Knapp HS, David JM, Small TJ, Kimos MC, Qin D, Pan J, Uzdilla LA, Gibbs, SK, Pokhrel PS, Vallejo RP, Yin, R. ANP Technologies, Inc., Newark, Del.

 

Abstract 36  

Design software for application specific microfluidic devices.
Bedekar AS, Krishnamoorthy S, Siddhaye SS, Wang Y, Malin SF. CFD Research Corporation, Huntsville, Ala.

 

Abstract 37  

A chip based microfluidic platform for high-performance, quantitative POC assays.
Öhman O, Mendel-Hartvig I, Lindström T, Read MC, Åmic AB, Uppsala Sweden.

 

Abstract 38  

A high-throughput antioxidant capacity assay using genetically engineered constructs sodA::gfp and katG::gfp as living sensors.
Lea W, Tolosa L, Rao G. Center for Advanced Sensor Technology, Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore County, Baltimore, Md.

 

Abstract 41  

Lysis of gram positive and gram negative bacteria on a disposable microfluidic chip.

Kulinski MD¹, Altman D¹, Singh S², and Klapperich CM¹,³. ¹Department of Manufacturing Engineering, Boston University, ²Boston University Medical Center, and ³Department of Biomedical Engineering, Boston University.

 
Abstract 42

Fast, accurate SNP detection using high resolution thermal melt analysis on a microfluidic chip.
Boles DJ1, Rulison A2, Dong W2, Knight IT1. 1Canon U.S. Life Sciences, Inc., Rockville, Md., and 2 Caliper Life Sciences Inc., Mountain View, Calif.

 

Abstract 43  

High sensitivity detection of cytokines and chemokines using fluorescence single-molecule counting assays.
Qiu H1, Ferrell E1, Nolan N2, Phelps B2, Tabibiazar R2, Nalefski E1, Whitney D1. 1US Genomics, Woburn, Mass., and 2 Aviir, Palo Alto, Calif.

 

Abstract 44

Measurements of the specific activity of antibodies immobilized on carboxylic acid modified beads for magnetic bead immunoassays.
Finne E, Weng E, Brandsæter W, Bremnæs C, Fonnum G. Invitrogen Corporation, Dynal Bead Based Separation, Oslo, Norway.

 

Abstract 45

Electronic cell sensor array technology for real-time, label-free cell-based assays .
Abassi YA, Atienza JM, Kirstein SL, Yu N, Xi B, O’Connell J, Wang X, Xu X. ACEA Biosciences, Inc., San Diego, Calif.

 

Abstract 46  

Comparison of propranolol quantitation using GC/MS-EI vs GC/MS-CI and the optimization of liquid-liquid extraction.
Anding KH, Moody CM, Lykissa ED. Expertox Inc., Deer Park, Texas.

 

Abstract 47

Population-scale HLA typing, based on self-assembling Genomics USA microarrays.
Eggers R, Fofanov1 Y, Jayaraman K, O’Brien K2, Hogan ME21Department of Computer Science, University of Houston, Houston, Texas, and 2Genomics USA, Hoffman Estates, Ill.

 

Abstract 48

Development of a fiber optic biosensor for breast cancer biopsy screening.
Erb
JL1
, Kruer TL2, Wittliff JL2 , Smith RH1, Downward JG, Andres SS2. 1ThreeFold Sensors, Ann Arbor, Mich., and 2Hormone Receptor Laboratory of the University of Louisville, Louisville, Ky.

 

Abstract 49

Development of a novel, rapid, and sensitive immunochromatographic strip assay specific for West Nile virus IgM and its clinical efficacy in patients suspected of West Nile virus infection.
Shaikh NA1, 2, Ge J2, Zhao YX2, Drebot MA3. 1Dept. of Laboratory Medicine & Pathobiology, University of Toronto, Canada, 2Spectral Diagnostics Inc., Toronto, Canada, and 3National Microbiology Laboratory, Winnipeg, Manitoba, Canada.

 

Abstract 50  

Clinical and analytical evaluation of point-of-care testing on waived analytes performed by non-laboratorians.
Kazmierczak SC1, Mansour MHM2, Bleile DM3, Aron K3. 1Oregon Health & Science University, Portland, Ore., 2American University in Cairo, Cairo, Egypt, and 3Abaxis Corp., Union City, Calif.

 

Abstract 51

Rapid isothermal DNA amplification coupled with visual or electronic detection using DNA-functionalized gold nanospheres.    
Tan E, Han Y, Erwin B, Buechel M, Candebat D, Niemz A.  Keck Graduate Institute, Claremont, Calif.

 

Abstract 52

Rapid detection of Chlamydia trachomatis in human urine using a B cell-based biosensor.
Mielzynska I, Hazel TG, Innovative Biosensors, Inc., College Park, Md.

 

Abstract 53

A novel, high throughput 2-dimensional cell migration and invasion assay.
Soltaninassab SR1, Sotos JP1, Bonds, MD1, Hansmann DD1, Israel BA1, Abbott NL1,2, Murphy CJ1,3.  1Platypus Technologies LLC, Madison, Wis., 2Chemical and Biological Engineering, University of Wisconsin, Madison, Wis., and 3Veterinary Medicine, University of Wisconsin, Madison, Wis.

 

Abstract 54

Rapid identification of bacteria by bacteriophage-enhanced immunoassay.
Bush D1

1 MicroPhage, Inc.  Longmont, Colo.

 

Abstract 55

Validation of a multiplex assay for comprehensive genotyping of drug metabolic enzyme and transporter gene polymorphisms.
Dumaual CM1, Daly TM1, Farmen M1, Lewin-Koh N1, Bauer N1, Miao X2, Bruckner C2, Close-Kirkwood S1, Hardenbol P2, Hockett RD.2 1Genomic Medicine Group, Diagnostic and Experimental Medicine, Eli Lilly and Company, Indianapolis, Ind., and 2Affymetrix, South San Francisco, Calif.

 

Abstract 56

Chaotic hemoglobin A1c status portends a central role in diabetes monitoring for glycated albumin, especially for type 2 patients.  
Roohk HV1, Gugliucci A2, Bernett G E3, Zaidi A4.. 1 Department of Surgery University of California Irvine, 2 Touro University, Calif., 3Bernett Laboratories, Calif., and 4 Epinex Diagnostics Inc., Irvine, Calif.

 

Abstract 57

Interrogation of the plasma proteome with differential scanning calorimetry.
Miller JJ1, Garbett NC2, Jenson AB2, Miller DM2, Chaires JB2. 1Department of Pathology & Laboratory Medicine, and 2James Graham Brown Cancer Center, University of Louisville, Louisville, Ky.

 

Abstract 58

A rapid, homogeneous assay platform for detecting drugs in oral fluid using RapidFRETTM technology: amphetamines, cannabinoids, cocaine, methamphetamines, opiates and phencyclidine at SAMHSA cutoff levels.
Corneillie TM1,2, Pirio MR1, Butlin NG1,2, Sadakian J1, Tom HK1,2. 1Biostride, Inc., Redwood City, Calif., and 2Lumiphore, Inc., Redwood City, Calif.

 

Abstract 59

ViraQuant™: Development, evaluation, and clinical utility of a quantitative multiplexed viral load assay for CMV, EBV, HHV6, HHV7, and BKV.
Garcia EP1, Yen-Lieberman B2, Donahue J1, Ford D1, Wells P1, Slepnev V1. 1Primera Biosystems, Mansfield, Mass., and 2The Cleveland Clinic, Cleveland, Ohio.
 
 

 

Abstract 62  

Malarial antigen quantitation with cartridge-integrated slit capillary array micropumps and flow-chamber microarrays.
Laser DJ, Hardham CT, Kim J. Wave 80 Biosciences, Inc., San Francisco, Calif.

 

Abstract 63

Dynabeads® MyOne™ SILANE for total nucleic acid capture.
Bergholtz SL1, Berg ES2, Keiserud A1, Bremnæs C1, Lycke K1, Fonnum G1, Kjus NH1, Stene T1, Molteberg A1, Jonassen CM3, Olsvik E1. 1 Invitrogen Dynal, Oslo, Norway, 2Norwegian Institute of Public Health, Oslo, Norway, and 3National Veterinary Institute, Oslo, Norway.

 

Abstract 64

A new separation method for the analysis of blood lipoproteins.
Rambaldi DC,a Zattoni A1, Casolari S1, Reschiglian P1, Roessner D2,  Johann C2. 1Department of Chemistry “G.Ciamician”, Bologna, Italy, and  2Wyatt Technology Europe GmbH, Dernbach, Germany.

 

Abstract 66

Detecting Prostate-Specific Antigen (PSA) using nucleic acid detection immunoassay (NADIA).
Jablonski E, Klem R, Saunders R, Adams T. Iris Molecular Diagnostics, Carlsbad, Calif.

 

Abstract 67  

Multiplex molecular probing using gold nanorods.
Yu C, Irudayaraj J. Agric and Biological Engineering/Bindley Bioscience Center, Purdue University, West Lafayette, Ind.

 

Abstract 68

Selected ion flow tube—mass spectrometry (SIFT-MS) real-time determination of occupational solvents in urinary headspace.
Storer M1,2, Senthilmohan S2, George P1,2.

1CDHB and 2Syft Technologies Ltd., Christchurch, New Zealand.

 

Abstract 74

A tag-less method to sort stem cells.
Roda B1, Reschiglian P1, Zattoni A1, Virgili L1, Di Carlo A1, Alviano F2, Lanzoni G2, Bonsi L2, Bagnara GP2. 1Department of Chemistry “G. Ciamician”, Via Selmi 2, 2Department of Histology, Embryology, and Applied Biology, Bologna, Italy.

 

Abstract 76  

Protein chips—“multi-parameter-analysis”—from development to clinical applications.
Hornauer H, Klause U, Müller H-J, Paul H, Risse B. Roche Diagnostics GmbH, New Systems/Modules, Penzberg, Germany.

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