Harnessing New Technology for Clinical Diagnostics
April 19 & 20, 2007
Hyatt Regency at Union Station
St. Louis, Missouri
2007 Oak Ridge Conference Abstract Titles
A novel technology platform for the ultrasensitive detection of cardiac troponin I (cTnI): Clinical utility in the emergency department.
Shipp G. Nanosphere, Inc., Northbrook, Ill.
Optically stimulated piezofilm detection—a novel, sensitive, non-separation assay designed for point-of-care applications.
Ross SA, Carter TJN. Vivacta Limited, Kent Science Park, UK.
Positive identification of patient samples using polymorphic DNA sequences as internal markers: the barcode of the future?
Haliassos A1,2, Drakoulis N3.
1 Greek External Quality Assesment Scheme , Athens, Greece, 2Diamedica S.A., Athens, Greece, and 3University of Athens, Athens, Greece.
Multiplexing diagnosis of human infectious diseases.
Conant CG, McLaughlin S, Mollova ET, Patil V, Zhang M, Cameron D, Gilmanshin R. U.S.Genomics, Woburn, Mass.
Inhibitor-resistant Forced Enzyme complementation based homogeneous immunoassay.
De Las Heras R, Li J, Fry S, McCourt J, Huang C, Arel E, Hazell S, Kachab E. Panbio Ltd., Brisbane, Australia.
Application of forced enzyme complementation technology: The detection of IgG antibodies to Herpes Simplex Virus in a homogeneous immunoassay.
De Las Heras R, Li J, Fry S, McCourt J, Huang C, Arel E, Hazell S, Kachab E. Panbio Ltd, Brisbane, Australia.
Isolation of viral RNA from infected mammalian cells on a disposable plastic microchip for low-cost, point-of-care diagnostics.
Bhattacharyya A1, Klapperich
CM1, 2. 1Department of Biomedical Engineering, Boston University, Boston, Mass., and 2Department of Manufacturing Engineering, Boston University, Boston, Mass.
A lab-on-a-film chip (LOFC) microfluidic diagnostic device capable of quantitative electrochemical immuno-enzymatic assays.
Kim YH1, Park JH1, Nam H2, Choi MH2, Jung SH2. 1Nano-Ditech Corporation, Monmouth Junction, N.J., and 2i-Sens Corporation, Seoul, Korea.
Detection of lung cancer patients with novel biomarker panels.
Li ZQ, Verch T, Allard WJ. Fujirebio Diagnostics, Inc., Malvern, Pa.
Quantitative, reproducible, sensitive fluorescent lateral flow assays: Next generation performance based on appropriate design and manufacturing principles and a portable fluorescent reader system.
O’Farrell B. Diagnostic Consulting Network, Carlsbad, Calif.
A handheld immunosensing device based on low-cost, self-contained microfluidic devices and ferromagnetic actuation .
Robillot C1, Fitzpatrick J1, Grimmer S1, Kettle B1, Dadic D2, Drese K2. 1Cleveland Biosensors Pty Ltd, Brisbane, Australia, and 2Institut f ü r Mikrotechnik, Mainz, Germany.
Determination of PSA and CRP using a reliable POCT system.
Maeda Y1, Kawaguchi T1, Nozue K2, Matsuda T 3, Komoda T 4. 1SEIKEN Co. Ltd, Tokyo, Japan, 2Bio Cyber Co. Ltd, Shizuoka, Japan, 3ASKA Special Laboratory Co. Ltd, Kanagawa, Japan, and 4Saitama Medical University, Saitama, Japan.
A novel method for cell lysis for the rapid detection of intracellular protein using paramagnetic particles.
Sharif EA, McLeod JD, Luxton RW. University of the West of England, Bristol, UK.
Development of a sensitive luminescence immunoassay (LIA) for glutamate in biological fluids.
Van Faassen HJR1, Meppelink GM1, Booltink E1, and Manz B1. 1Labor Diagnostika Nord, Nordhorn, Germany.
The LiMA technology: Measurement of ATP on a NAT platform.
Banin S, Wilson S, Stanley C. ISEAO Technologies Ltd, London, UK.
The use of antibody coated paramagnetic particles as a label for the rapid detection of PSA.
Sharif EA, Hawkins P, Kiely J, Luxton RW. University of the West of England, Bristol, UK.
Robust horseradish peroxidase catalyzed chemiluminescence technology for microtiter plate based immuno-diagnostic assays.
Kumar A, Kalra B. Diagnostic Systems Laboratories-Beckman Coulter Inc., Webster, Texas.
Lanthanide phosphate nanorods can be used as inorganic fluorescent label in cell biology research.
Chittaranjan P, Resham B, Sujata P, Sujit B, Priyabrata M, Debabrata M. Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minn.
A fully automated nucleic acid detection technology.
Nurmi J, Syrjälä A, Hagren V, von Lode P. Abacus Diagnostica Ltd., Turku, Finland.
Stabilization of dried PCR reagents.
Nurmi J, Hagren V, Syrjälä A, von Lode P.
Abacus Diagnostica Ltd., Turku, Finland.
Evaluation of automated calculation of mean blood glucose (MBG) values from a POCT instrument in correlation with glycated hemoglobin (HbA1c).
Makris K1, Spanou L1, Drakopoulos I1, Katritsis D2, Vlahou M1, Haliassos A3. 1Clinical Biochemistry Laboratory, K.A.T. General Hospital, Kiffisia, Greece, 2Cardiology Department, Athens Euroclinic, Athens, Greece, and 3Greek External Quality Assessment Scheme (GEQAS), Greece.
Non-invasive monitoring of glucose and hemoglobin.
Ma'ayan L, Primack H, Weinstein A. OrSense Ltd., Nes-Ziona, Israel.
High magnetization magnetic beads for fast magnetic separation.
Fujii S, Nakabayashi T, Kaneko Y, Adachi M, Tokoro H. Hitachi Metals Ltd., Saitama, Japan.
A point-of care test design using sequential immunoassay for sensitive detection of specific IgE antibodies.
Nystrand M, Jonsson A, Holmquist S, Matsson P. Phadia AB, Uppsala, Sweden.
Rapid (15 min) microfluidic microarray hybridization using target single-stranded DNA produced by selective digestion with Lambda exonuclease.
Boissinot K1*, Huletsky A1, Peytavi R1, Turcotte S1, Boissinot M1, Picard FJ1, Bergeron MG1. 1Centre de Recherche en Infectiologie, Université Laval, Québec City, Canada.
The NIDS® technology: Nanomanipulation of bioactive molecules on particle surfaces enabling increased sensitivity, multiplexing and quantitation in rapid diagnostic tests.
Knapp HS, David JM, Small TJ, Kimos MC, Qin D, Pan J, Uzdilla LA, Gibbs, SK, Pokhrel PS, Vallejo RP, Yin, R. ANP Technologies, Inc., Newark, Del.
Design software for application specific microfluidic devices.
Bedekar AS, Krishnamoorthy S, Siddhaye SS, Wang Y, Malin SF. CFD Research Corporation, Huntsville, Ala.
A chip based microfluidic platform for high-performance, quantitative POC assays.
Öhman O, Mendel-Hartvig I, Lindström T, Read MC, Åmic AB, Uppsala Sweden.
A high-throughput antioxidant capacity assay using genetically engineered constructs sodA::gfp and katG::gfp as living sensors.
Lea W, Tolosa L, Rao G. Center for Advanced Sensor Technology, Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore County, Baltimore, Md.
Lysis of gram positive and gram negative bacteria on a disposable microfluidic chip.
Kulinski MD¹, Altman D¹, Singh S², and Klapperich CM¹,³. ¹Department of Manufacturing Engineering, Boston University, ²Boston University Medical Center, and ³Department of Biomedical Engineering, Boston University.
Fast, accurate SNP detection using high resolution thermal melt analysis on a microfluidic chip.
Boles DJ1, Rulison A2, Dong W2, Knight IT1. 1Canon U.S. Life Sciences, Inc., Rockville, Md., and 2 Caliper Life Sciences Inc., Mountain View, Calif.
High sensitivity detection of cytokines and chemokines using fluorescence single-molecule counting assays.
Qiu H1, Ferrell E1, Nolan N2, Phelps B2, Tabibiazar R2, Nalefski E1, Whitney D1. 1US Genomics, Woburn, Mass., and 2 Aviir, Palo Alto, Calif.
Measurements of the specific activity of antibodies immobilized on carboxylic acid modified beads for magnetic bead immunoassays.
Finne E, Weng E, Brandsæter W, Bremnæs C, Fonnum G. Invitrogen Corporation, Dynal Bead Based Separation, Oslo, Norway.
Electronic cell sensor array technology for real-time, label-free cell-based assays .
Abassi YA, Atienza JM, Kirstein SL, Yu N, Xi B, O’Connell J, Wang X, Xu X. ACEA Biosciences, Inc., San Diego, Calif.
Comparison of propranolol quantitation using GC/MS-EI vs GC/MS-CI and the optimization of liquid-liquid extraction.
Anding KH, Moody CM, Lykissa ED. Expertox Inc., Deer Park, Texas.
Population-scale HLA typing, based on self-assembling Genomics USA microarrays.
Eggers R, Fofanov1 Y, Jayaraman K, O’Brien K2, Hogan ME2. 1Department of Computer Science, University of Houston, Houston, Texas, and 2Genomics USA, Hoffman Estates, Ill.
Development of a fiber optic biosensor for breast cancer biopsy screening.
Erb JL1 , Kruer TL2, Wittliff JL2 , Smith RH1, Downward JG, Andres SS2. 1ThreeFold Sensors, Ann Arbor, Mich., and 2Hormone Receptor Laboratory of the University of Louisville, Louisville, Ky.
Development of a novel, rapid, and sensitive immunochromatographic strip assay specific for West Nile virus IgM and its clinical efficacy in patients suspected of West Nile virus infection.
Shaikh NA1, 2, Ge J2, Zhao YX2, Drebot MA3. 1Dept. of Laboratory Medicine & Pathobiology, University of Toronto, Canada, 2Spectral Diagnostics Inc., Toronto, Canada, and 3National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
Clinical and analytical evaluation of point-of-care testing on waived analytes performed by non-laboratorians.
Kazmierczak SC1, Mansour MHM2, Bleile DM3, Aron K3. 1Oregon Health & Science University, Portland, Ore., 2American University in Cairo, Cairo, Egypt, and 3Abaxis Corp., Union City, Calif.
Rapid isothermal DNA amplification coupled with visual or electronic detection using DNA-functionalized gold nanospheres.
Tan E, Han Y, Erwin B, Buechel M, Candebat D, Niemz A. Keck Graduate Institute, Claremont, Calif.
Rapid detection of Chlamydia trachomatis in human urine using a B cell-based biosensor.
Mielzynska I, Hazel TG, Innovative Biosensors, Inc., College Park, Md.
A novel, high throughput 2-dimensional cell migration and invasion assay.
Soltaninassab SR1, Sotos JP1, Bonds, MD1, Hansmann DD1, Israel BA1, Abbott NL1,2, Murphy CJ1,3. 1Platypus Technologies LLC, Madison, Wis., 2Chemical and Biological Engineering, University of Wisconsin, Madison, Wis., and 3Veterinary Medicine, University of Wisconsin, Madison, Wis.
Rapid identification of bacteria by bacteriophage-enhanced immunoassay.
1 MicroPhage, Inc. Longmont, Colo.
Validation of a multiplex assay for comprehensive genotyping of drug metabolic enzyme and transporter gene polymorphisms.
Dumaual CM1, Daly TM1, Farmen M1, Lewin-Koh N1, Bauer N1, Miao X2, Bruckner C2, Close-Kirkwood S1, Hardenbol P2, Hockett RD.2 1Genomic Medicine Group, Diagnostic and Experimental Medicine, Eli Lilly and Company, Indianapolis, Ind., and 2Affymetrix, South San Francisco, Calif.
Chaotic hemoglobin A1c status portends a central role in diabetes monitoring for glycated albumin, especially for type 2 patients.
Roohk HV1, Gugliucci A2, Bernett G E3, Zaidi A4.. 1 Department of Surgery University of California Irvine, 2 Touro University, Calif., 3Bernett Laboratories, Calif., and 4 Epinex Diagnostics Inc., Irvine, Calif.
Interrogation of the plasma proteome with differential scanning calorimetry.
Miller JJ1, Garbett NC2, Jenson AB2, Miller DM2, Chaires JB2. 1Department of Pathology & Laboratory Medicine, and 2James Graham Brown Cancer Center, University of Louisville, Louisville, Ky.
A rapid, homogeneous assay platform for detecting drugs in oral fluid using RapidFRETTM technology: amphetamines, cannabinoids, cocaine, methamphetamines, opiates and phencyclidine at SAMHSA cutoff levels.
Corneillie TM1,2, Pirio MR1, Butlin NG1,2, Sadakian J1, Tom HK1,2. 1Biostride, Inc., Redwood City, Calif., and 2Lumiphore, Inc., Redwood City, Calif.
ViraQuant™: Development, evaluation, and clinical utility of a quantitative multiplexed viral load assay for CMV, EBV, HHV6, HHV7, and BKV.
Garcia EP1, Yen-Lieberman B2, Donahue J1, Ford D1, Wells P1, Slepnev V1. 1Primera Biosystems, Mansfield, Mass., and 2The Cleveland Clinic, Cleveland, Ohio.
Malarial antigen quantitation with cartridge-integrated slit capillary array micropumps and flow-chamber microarrays.
Laser DJ, Hardham CT, Kim J. Wave 80 Biosciences, Inc., San Francisco, Calif.
Dynabeads® MyOne™ SILANE for total nucleic acid capture.
Bergholtz SL1, Berg ES2, Keiserud A1, Bremnæs C1, Lycke K1, Fonnum G1, Kjus NH1, Stene T1, Molteberg A1, Jonassen CM3, Olsvik E1. 1 Invitrogen Dynal, Oslo, Norway, 2Norwegian Institute of Public Health, Oslo, Norway, and 3National Veterinary Institute, Oslo, Norway.
A new separation method for the analysis of blood lipoproteins.
Rambaldi DC,a Zattoni A1, Casolari S1, Reschiglian P1, Roessner D2, Johann C2. 1Department of Chemistry “G.Ciamician”, Bologna, Italy, and 2Wyatt Technology Europe GmbH, Dernbach, Germany.
Detecting Prostate-Specific Antigen (PSA) using nucleic acid detection immunoassay (NADIA).
Jablonski E, Klem R, Saunders R, Adams T. Iris Molecular Diagnostics, Carlsbad, Calif.
Multiplex molecular probing using gold nanorods.
Yu C, Irudayaraj J. Agric and Biological Engineering/Bindley Bioscience Center, Purdue University, West Lafayette, Ind.
Selected ion flow tube—mass spectrometry (SIFT-MS) real-time determination of occupational solvents in urinary headspace.
Storer M1,2, Senthilmohan S2, George P1,2.
1CDHB and 2Syft Technologies Ltd., Christchurch, New Zealand.
A tag-less method to sort stem cells.
Roda B1, Reschiglian P1, Zattoni A1, Virgili L1, Di Carlo A1, Alviano F2, Lanzoni G2, Bonsi L2, Bagnara GP2. 1Department of Chemistry “G. Ciamician”, Via Selmi 2, 2Department of Histology, Embryology, and Applied Biology, Bologna, Italy.
Protein chips—“multi-parameter-analysis”—from development to clinical applications.
Hornauer H, Klause U, Müller H-J, Paul H, Risse B. Roche Diagnostics GmbH, New Systems/Modules, Penzberg, Germany.