Expert Access - Biomarkers of Sepsis: Sounding the Alarm

Katherine Soreng

Katherine Soreng, PhD

Thursday, September 22, 2011
1:00-2:00 pm Eastern (U.S.) time




Biomarkers of Sepsis: Sounding the Alarm

Sepsis is a complex clinical syndrome that is a leading cause of death worldwide. Bacterial pathogens represent the majority of infections associated with sepsis, making timely and appropriate treatment with antibiotics a key element in treatment protocols and improved outcomes. Pathogenesis is often associated with the "cytokine storm," a poorly controlled response of the immune system, which can lead to hemodynamic instability and organ failure. Clinical signs and symptoms alone are often insufficient for an early and accurate diagnosis, reducing an already limited window for effective intervention. This presentation will briefly review the medical definition, diagnosis, and epidemiology of sepsis, as well as some of the extensive published evidence suggesting clinical utility for procalcitonin, or PCT, as a useful biomarker of bacterial sepsis.


Dr. Soreng received her BS in Biology from the University of Washington in Seattle.  While completing her studies, she conducted clinical research on herpes viruses.  She was awarded a Ph.D. in Immunology and Molecular Pathogenesis from Emory University in Atlanta, GA, publishing a thesis on protein synthesis and cytoskeletal elements in the Class II restricted processing of antigen.

She submitted and won a grant from the ASM for a two-year post-doctoral appointment at the CDC for the investigation of the simian homologue of CD46 and its potential role as a measles virus receptor and mediator of pathogenesis.

Dr. Soreng currently heads the Clinical and Scientific Marketing team at Siemens Healthcare Diagnostics.  She both writes and manages the production of scientific and educational literature, including peer-reviewed publications, White papers, and other educational collateral such as PowerPoint’s on clinical diagnostics and disease state management.  She frequently lectures on topics in infectious disease, including HIV, hepatitis, and emerging markers in sepsis and liver disease, among other subjects

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