American Association for Clinical Chemistry
Better health through laboratory medicine
Recent Advances and Current Concepts in the Diagnosis and Monitoring of Sepsis: October 2007 Expert Access Presentation

 Patrick St. Louis, PhD
"Recent Advances and Current Concepts in the Diagnosis and Monitoring of Sepsis"


Sepsis continues to be a major clinical problem, with >500,000 cases annually in the USA and a mortality of 35%. The recognition of sepsis and its infectious case is problematic and there continues to be a lack of accepted rapid and specific diagnostic criteria. Further, laboratory tools for the monitoring of the disease and response to treatment are still inadequate. Recent studies seeking reliable markers of sepsis continue to look at components of the immune inflammatory system, markers of cellular activation and procalcitonin, among others.  This session will present an integrated view of recent studies on markers of sepsis. It will discuss why, individually, many markers fail to provide widely acceptable solutions to the problem and will address the approach using combinations of markers. It will also discuss current approaches using newer, molecular techniques. Indeed basic research studies on cellular signalling and activation are providing interesting ideas for molecules which may prove useful in the search for laboratory markers of sepsis.

Learning Objectives: After attending this session participants will be able to 1. Identify the clinical utility of presently suggested approaches to the diagnosis and monitoring of sepsis 2. Undertake or consult on the clinical evaluation of new markers or panels of markers of sepsis. 3. Consult effectively with clinical staff on the development of the evidence-based application of these tests