Heads Up: May 22, 2008

Alanine Aminotransferase and High Sensitivity CRP Protein: Correlates of Cardiovascular Risk Factors in Youth

Simultaneous measurements of ALT and CRP should be considered as a screening test for metabolic syndrome and CVD risk factors in overweight and obese youth, according to a recent paper. Brazilian researchers report that for every 5 cm increase in waist circumference and every 1 point increase in BMI, subjects had a 1.3 and 1.5 –fold greater chance of having increased ALT and CRP, respectively.

Thyrotropin Levels in a Population with No Clinical Autoantibody, or Ultrasonographic Evidence of Thyroid Disease: Implications for the Diagnosis of Subclinical Hypothyroidism

A recent study suggests narrowing the TSH reference range and changing the TSH upper-reference limit to a value of approximately 4.0. The study of a general community cohort found that the TSH distribution in the normal reference group was skewed. The best estimates of the 97.5th percentile, the percentage above 2.6 IU/ml, and the percentage above 3.0 Iu/ml for TSH by third generation immunochemiluminometric assay were 4.1 IU/ml, 20% and 10.2%, respectively.

Serum Uric Acid Is an Independent Predictor for All Major Forms of Cardiovascular Death in 28,613 Elderly Women: A Prospective 21-Year Follow-Up Study

In elderly, post-menopausal women, serum uric acid is an independent predictor for all major forms of death from CVD including acute, subacute, and chronic forms of CHD, CHF, and stroke. Serum uric acid in the highest quartile (≥5.41 mg/dL) was significantly associated with mortality from total CVD ( pb0.0001), showing a clear dose-response relationship. The adjusted hazard ratio (95% CI) in comparison to the lowest serum uric acid quartile was 1.35 (1.20–1.52).

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