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Figure 1
Folate Metabolism

Folates highlighted in red represent the major types found in blood with 5-MTHF exceeding all types (82–93%).

Abbreviations: B2; riboflavin, B6, pyridoxal phosphate, B12; cobalamin ,DHF; dihydrofolate, DHFR; dihydrofolate reductase, DMG; dimethylglycine, dTMP; deoxythymidine 5’-phosphate, dUMP; 2’-deoxyuridin-5’-phosphate, MS; methionine synthase, 5-MTHF; 5-methyltetrahydrofolate, MTHFR; methylene tetrahydrofolate reductase, SAM; S-adenosylmethionine, SAH; S-adenosylhomocysteine, SHMT; serine hydroxymethyltransferase, THF; tetrahydrofolate, TS; thymidylate synthetase, UMFA, unmetabolized folic acid.