American Association for Clinical Chemistry
Better health through laboratory medicine
February 2011 Clinical Laboratory News: HbA1c Figures

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Figure 1 
Nonenzymatic Glycation of Hemoglobin

Glucose reacts with an amino group on hemoglobin to form an aldimine linkage and subsequently undergoes an Amadori rearrangement to form a stable ketoamine (glycated hemoglobin).

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Figure 2
Laboratory Performance Data from the CAP GH-2 Survey

Each point and bar represents the mean result ±2SD, respectively, of laboratories using a particular method. The horizontal dotted line represents the NGSP/DCCT target value.

Symbols: ? results reported as HbA1c, ♦ results reported as HbA1, ? results reported as total GHB.