Clinical Chemistry's Q&A offers a rare opportunity to have a panel of experts at your fingertips. A moderator highlights a timely and important issue by questioning key experts in the field.
2013
Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics?
- Moderator: Carlo Brugnara
- Experts: John Adamson, Michael Auerbach, Robert Kane, Iain Macdougall, and Alan Mast
- DOI: 10.1373/clinchem.2012.182071
Communication of Scientific Information: Is It Time to Reassess?
- Moderators: Nader Rifai and John Sack
- Experts: Michael A. Keller, Anurag Acharya, Philip E. Bourne, Mike Rossner, and Stewart Wills
- DOI: 10.1373/clinchem.2012.194738
Pheochromocytoma
- Moderators: Mathew P. Estey and Eleftherios P. Diamandis
- Experts: Graeme Eisenhofer, Karel Pacak, Eamonn R. Maher, William F. Young, and Ronald R. de Krijger
- DOI: 10.1373/clinchem.2012.182246
MicroRNA Analysis: Is It Ready for Prime Time?
- Moderator: Gregory J. Tsongalis
- Experts: George Calin, Pierre Cordelier, Carlo Croce, Federico Monzon, and Anna E. Szafranska-Schwarzbach
- DOI: 10.1373/clinchem.2012.185009
Pancreatic Cancer
- Moderators: Caitlin C. Chrystoja and Eleftherios P. Diamandis
- Experts: Randall Brand, Felix Rückert, Randy Haun, and Rafael Molina
- DOI: 10.1373/clinchem.2012.196642
2012
NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: Can We Clarify the Controversy about Cholesterol Screening and Treatment in Childhood?
- Moderator: Sarah D. de Ferranti
- Experts: Stephen R. Daniels, Matthew Gillman, Louis Vernacchio, Jorge Plutzky, and Annette L. Baker
- DOI: 10.1373/clinchem.2012.182089
Autoimmune Diseases: Early Diagnosis and New Treatment Strategies
- Moderators: Danijela Konforte and Eleftherios P. Diamandis
- Experts: Walther J. van Venrooij, Rik Lories, and Michael M. Ward
- DOI: 10.1373/clinchem.2012.189480
Thyroid Function during Pregnancy: Who and How Should We Screen?
- Moderator: Ann M. Gronowski
- Experts: James Haddow, Sarah Kilpatrick, John H. Lazarus, and Roberto Negro
- DOI: 10.1373/clinchem.2012.185017
Ectopic Pregnancy
- Moderators: Julie L.V. Shaw and Eleftherios P. Diamandis
- Experts: Andrew Horne, Kurt Barnhart, Tom Bourne, and Ioannis E. Messinis
- DOI: 10.1373/clinchem.2012.184168
Antibiotic Resistance: How Serious Is the Problem, and What Can Be Done?
- Moderators: Alexander J. McAdam
- Experts: David C. Hooper, Alfred DeMaria, Brandi M. Limbago, Thomas F. O'Brien, and Betsy McCaughey
- DOI: 10.1373/clinchem.2011.181636
Altering the Landscape for Women in Clinical Chemistry: Perspectives from Multigenerational Leaders
- Moderators: Shannon Haymond and Amy K. Saenger
- Experts: Helen M. Free, Jocelyn M. Hicks, Marilyn A. Huestis, Rita Horvath, and Corinne R. Fantz
- DOI: 10.1373/clinchem.2011.174284
The Obesity Epidemic
- Moderators: Jennifer Shea and Eleftherios P. Diamandis
- Experts: Arya M. Sharma, Jean-Pierre Després, Shereen Ezzat, and Frank Greenway
- DOI: 10.1373/clinchem.2011.180976
Liquid Chromatography-Tandem Mass Spectrometry or Automated Immunoassays: What Are the Future Trends in Therapeutic Drug Monitoring?
- Moderators: Gunnar Brandhorst and Michael Oellerich
- Experts: Gregory Maine, Paul Taylor, Gerhard Veen, and Pierre Wallemacq
- DOI: 10.1373/clinchem.2011.167189
Is Leadership a Noun or Verb?
- Moderator: Thomas M. Annesley
- Experts: James S. Hernandez, Angie Morgan, Ora Pescovitz, and Ian Wright
- DOI: 10.1373/clinchem.2011.165639
How Well Are We Training the Next Generation of Clinical Pathologists and Clinical Laboratory Directors? A Global Perspective
- Moderator: Mitchell G. Scott
- Experts: Brian R. Smith, Alan H.B. Wu, Ian S. Young, Mario Plebani, and Rossa W.K. Chiu
- DOI: 10.1373/clinchem.2011.171199
Newborn Screening for Metabolic Disorders: How Are We Doing, and Where Are We Going?
- Moderator: Michael J. Bennett
- Experts: Piero Rinaldo, Bridget Wilcken, Kenneth A. Pass, Michael S. Watson, and Ronald J.A. Wanders
- DOI: 10.1373/clinchem.2011.171215
The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers
- Moderators: Fred S. Apple and David Morrow
- Experts: Christian Zaugg, David Hickey, Michelle Zaharik, John J. Blackwood, and Kirsten Jakobsen
- DOI: 10.1373/clinchem.2011.165860
2011
Invest or Not to Invest ... Not Always an Easy Question to Answer
- Moderator: Susan Evans
- Experts: Emery Stephans, Avi Kulkarni, Aaron Geist and Quintin Lai
- DOI: 10.1373/clinchem.2010.152132
Direct-to-Consumer Genetic Testing: Reliable or Risky?
- Moderators: David H. Spencer and Christina Lockwood
- Experts: Eric Topol, James P. Evans, Robert C. Green, Elizabeth Mansfield, and Zivana Tezak
- DOI: 10.1373/clinchem.2011.167197
Circulating Cancer Cells and Their Clinical Applications
- Moderator: Eleftherios P. Diamandis
- Experts: Klaus Pantel, Howard I. Scher, Leon Terstappen, and Evi Lianidou
- DOI: 10.1373/clinchem.2011.166678
Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care
- Moderator: Andrew N. Hoofnagle
- Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
- DOI: 10.1373/clinchem.2010.158311
Clinical Applications for Vitamin D Assays: What Is Known and What Is Wished for
- Moderator: Michael Kleerekoper
- Experts: Rosemary L. Schleicher, John Eisman, Roger Bouillon, Ravinder J. Singh and Michael F. Holick
- DOI: 10.1373/clinchem.2010.154997
Oral Fluid Testing: Promises and Pitfalls
- Moderator: Marilyn A. Huestis
- Experts: Alain Verstraete, Tai C. Kwong, Jorg Morland, Michael J. Vincent, and Raphael de la Torre
- DOI: 10.1373/clinchem.2010.152124
Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy
- Moderators: Maria Diamandis Pasic and Eleftherios P. Diamandis
- Experts: JoAnne McLaurin, David M. Holtzman, Gerold Schmitt-Ulms, and Rémi Quirion
- DOI: 10.1373/clinchem.2011.161828
Individually Tailored Immunosuppression: Is There a Role for Biomarkers?
- Moderators: Gunnar Brandhorst and Michael Oellerich
- Experts: Mercè Brunet, Richard Kowalski, Alexander Vinks and Pierre Wallemacq
- DOI: 10.1373/clinchem.2010.159871
The Quest for Clean Competition in Sports: Are the Testers Catching the Dopers?
- Moderator: Anthony W. Butch
- Experts: John A. Lombardo, Larry D. Bowers, Julie Chu and David A. Cowan
- DOI: 10.1373/clinchem.2010.155002
The Use of Human Tissues in Research: What Do We Owe the Research Subjects?
- Moderator: Ann M. Gronowski
- Experts: Jack Moye, Jr., David S. Wendler, Arthur L. Caplan and Michael Christman
- DOI: 10.1373/clinchem.2010.154989
2010
Cancer Genomes
- Moderator: Eleftherios P. Diamandis
- Experts: Thomas Hudson, Olli Kallioniemi, Edison T. Liu and Carlos López-Otín
- DOI: 10.1373/clinchem.2010.152140
Nanotechnology: Improving Clinical Testing?
- Moderators: Paolo Fortina and Larry J. Kricka
- Experts: Dawn Bonnell, Amit Kulkarni, Joseph Wang, Yuri Miyahara, and David Ure
- DOI: 10.1373/clinchem.2009.138750
Epigenomics-Based Diagnostics
- Moderator: Eleftherios P. Diamandis
- Experts: David Sidransky, Peter W. Laird, Paul Cairns and Bharati Bapat
- DOI: 10.1373/clinchem.2010.148007
Direct-to-Consumer Genotyping: Are We Ready for a Brave New World?
- Moderators: Mark A. Cervinski and Gregory J. Tsongalis
- Experts: Lew Bender, Lawrence M. Silverman, Mary Bet Dinulos, Jim Nickel and Wayne Grody
- DOI: 10.1373/clinchem.2009.138743
High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?
- Moderator: Fred S. Apple
- Experts: Alan Wu, Paul Collinson, Allan Jaffe and David Morrow
- DOI: 10.1373/clinchem.2009.138727
KRAS Mutation Detection: A New Look at an Old Gene
- Moderators: Joel A. Lefferts and Gregory J. Tsongalis
- Experts: Arief A. Suriawinata, William K. Funkhouser, Marc Ladanyi, Jan A. Nowak and J. Marc Pipas
- DOI: 10.1373/clinchem.2009.138735
Microtechnology in the Clinical Laboratory: Will It Solve Analytical Problems, and When Will It Make an Impact?
- Moderator: Peter Wilding
- Experts: Sabeth Verpoorte, M. Allen Northrup, Paul Yager, Stephen Quake and James Landers
- DOI: 10.1373/clinchem.2009.138719
Prostate Cancer Screening with Prostate-Specific Antigen Testing: More Answers or More Confusion?
- Moderator: Eleftherios P. Diamandis
- Experts: Patrick Walsh, Klaus Jung, William Catalona and Neil Fleshner
- DOI: 10.1373/clinchem.2009.140046
Detection of Biological Agents Used for Terrorism: Are We Ready?
- Moderator: Mark Kellogg
- Experts: Mark Hollis, Cheryl Gauthier, and Tom O'Brien
- DOI: 10.1373/clinchem.2009.139493
2009
Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?
- Moderator: Eleftherios P. Diamandis
- Experts: Karl V. Voelkerding, Rade Drmanac, David Agus and John McPherson
- DOI: 10.1373/clinchem.2009.133389
Clinical Assays for Human Chorionic Gonadotropin: What Should We Measure and How?
- Moderator: Ann M. Gronowski
- Experts: Catherine Sturgeon, Ulf-Håkan Stenman, Glenn D. Braunstein, Anthony W. Butch and David A. Cowan
- DOI: 10.1373/clinchem.2009.133595
Tight Glucose Control in Critically Ill Patients: Should Glucose Meters Be Used?
- Moderator: David B. Sacks
- Experts: Greet Van den Berghe, Sue Kirkman, Gerald Kost, Ron Ng and Sverre Sandberg
- DOI: 10.1373/clinchem.2009.131318
Protein Quantification by Mass Spectrometry: Is It Ready for Prime Time?
- Moderator: Eleftherios P. Diamandis
- Experts: Samir Hanash, Mary Lopez, Steven Carr, and Emanuel F. Petricoin III
- DOI: 10.1373/clinchem.2009.128058
Mass Spectrometry in the Clinical Laboratory: How Have We Done, and Where Do We Need to Be?
- Moderator: Thomas Annesley
- Experts: Joseph Majzoub, Ann Hsing, Alan Wu, Alan Rockwood and Donald Mason
- DOI: 10.1373/clinchem.2009.127522