Clinical Chemistry's  Q&A offers a rare opportunity to have a panel of experts at your fingertips.  A moderator highlights a timely and important issue by questioning key experts in the field. 


What Is Wrong with Clinical Proteomics?

  • Moderators: Ashley Di Meo and Eleftherios P. Diamandis
  • Experts: Henry Rodriguez, Andrew N. Hoofnagle, John Ioannidis, and Mary Lopez
  • DOI: 10.1373/clinchem.2014.225185

Registering Diagnostic and Prognostic Trials of Tests: Is It the Right Thing to Do?

  • Moderators: Nader Rifai and Patrick M.M. Bossuyt
  • Experts: John P.A. Ioannidis, Kurtis R. Bray, Lisa M. McShane, Robert M. Golub, and Lotty Hooft
  • DOI: 10.1373/clinchem.2014.226100

Natriuretic Peptides in Heart Failure

  • Moderators: Danny C.C. Lin and Eleftherios P. Diamandis
  • Experts: James L. Januzzi Jr., Alan Maisel, Allan S. Jaffe, and Aldo Clerico
  • DOI: 10.1373/clinchem.2014.223057

Harmonization of Test Results: What Are the Challenges; How Can We Make It Better?

  • Moderator: W. Greg Miller
  • Experts: John H. Eckfeldt, Joseph Passarelli, William Rosner, and Ian S. Young
  • DOI: 10.1373/clinchem.2012.201186

Novel Biomarkers for Acute Myocardial Infarction: Is MicroRNA the New Kid on the Block?

  • Moderators: Joshua E. Raizman and Eleftherios P. Diamandis
  • Experts: Katey Rayner, Stephanie Dimmeler, George A. Calin, and Thomas Thum
  • DOI: 10.1373/clinchem.2013.215491

Interferon γ–Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons

  • Moderators: Nira R. Pollock and Alexander J. McAdam
  • Experts: Madhukar Pai, Edward A. Nardell, John Bernardo, Niaz Banaei, and Jay Mobo
  • DOI: 10.1373/clinchem.2012.201178

Helicobacter pylori  Diagnostics and Treatment: Could a Lack of Universal Consensus Be the Best Consensus?

  • Moderator: Marc R. Couturier
  • Experts: Barry J. Marshall, Karen J. Goodman, and Francis Mégraud
  • DOI: 10.1373/clinchem.2012.201475

Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now?

  • Moderator: Brad S. Karon
  • Experts: Gilles Montalescot, Neil S. Harris, Søren Risom Kristensen, and Matthew Price
  • DOI: 10.1373/clinchem.2013.208942

Biomarkers for Acute Kidney Injury: Where Are We Today? Where Should We Go?

  • Moderator: John C. Lieske
  • Experts: Lakhmir Chawla, Kianoush Kashani, John A. Kellum, Jr., Jay L. Koyner, and Ravindra L. Mehta
  • DOI: 10.1373/clinchem.2012.201988

The Ethical Implications of Preimplantation Genetic Diagnosis

  • Moderator: Ann M. Gronowski
  • Experts: Richard T. Scott, Jr., Arthur L. Caplan, and Lawrence J. Nelson
  • DOI: 10.1373/clinchem.2013.202515


Automation in the Clinical Microbiology Laboratory

  • Moderator: Carey-Ann D. Burnham
  • Experts: W. Michael Dunne, Jr., Gilbert Greub, Susan M. Novak, and Robin Patel
  • DOI: 10.1373/clinchem.2012.201038

Identifying Antibiotic-Resistant Bacteria in Hospitalized Patients: What Is the Role of Active-Surveillance Cultures?

  • Moderator: Thomas J. Sandora
  • Experts: Susan A. Dolan, Stephan Harbarth, Susan S. Huang, Alexander J. McAdam, and Aaron M. Milstone
  • DOI: 10.1373/clinchem.2012.201046

Use of MALDI-TOF for Diagnosis of Microbial Infections

  • Moderators: Dana Bailey and Eleftherios P. Diamandis
  • Experts: Gilbert Greub, Susan M. Poutanen, Jens Jørgen Christensen, and Markus Kostrzew
  • DOI: 10.1373/clinchem.2013.204644

Bioinformatics: What the Clinical Laboratorian Needs to Know and Prepare For

  • Moderator: Gregory J. Tsongalis
  • Experts: Elizabeth Chao, Jill M. Hagenkord, Tina Hambuch, and Jason H. Moore
  • DOI: 10.1373/clinchem.2012.198226

A New Era in Prenatal Diagnosis: The Use of Cell-Free Fetal DNA in Maternal Circulation for Detection of Chromosomal Aneuploidies

  • Moderators: Jennifer L. Shea and Eleftherios P. Diamandis
  • Experts: Barry Hoffman, Y.M. Dennis Lo, Jacob Canick, and Dirk van den Boom
  • DOI: 10.1373/clinchem.2012.201996

FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?

  • Moderator: Mitchell G. Scott
  • Experts: Edward R. Ashwood, Thomas M. Annesley, Debra G.B. Leonard, and Michael C. Burgess
  • DOI: 10.1373/clinchem.2013.204958

Cobalt and Chromium Measurement in Patients with Metal Hip Prostheses

  • Moderators: Mathew P. Estey and Eleftherios P. Diamandis
  • Experts: Catherine Van Der Straeten, Stephen S. Tower, Alister J. Hart, and Thomas P. Moyer
  • DOI: 10.1373/clinchem.2012.193037

Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics?

  • Moderator: Carlo Brugnara
  • Experts: John Adamson, Michael Auerbach, Robert Kane, Iain Macdougall, and Alan Mast
  • DOI: 10.1373/clinchem.2012.182071

Communication of Scientific Information: Is It Time to Reassess?

  • Moderators: Nader Rifai and John Sack
  • Experts: Michael A. Keller, Anurag Acharya, Philip E. Bourne, Mike Rossner, and Stewart Wills
  • DOI: 10.1373/clinchem.2012.194738


  • Moderators: Mathew P. Estey and Eleftherios P. Diamandis
  • Experts: Graeme Eisenhofer, Karel Pacak, Eamonn R. Maher, William F. Young, and Ronald R. de Krijger
  • DOI: 10.1373/clinchem.2012.182246

MicroRNA Analysis: Is It Ready for Prime Time?

  • Moderator: Gregory J. Tsongalis
  • Experts: George Calin, Pierre Cordelier, Carlo Croce, Federico Monzon, and Anna E. Szafranska-Schwarzbach
  • DOI: 10.1373/clinchem.2012.185009

Pancreatic Cancer

  • Moderators: Caitlin C. Chrystoja and Eleftherios P. Diamandis
  • Experts: Randall Brand, Felix Rückert, Randy Haun, and Rafael Molina
  • DOI: 10.1373/clinchem.2012.196642


NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: Can We Clarify the Controversy about Cholesterol Screening and Treatment in Childhood?

  • Moderator: Sarah D. de Ferranti
  • Experts: Stephen R. Daniels, Matthew Gillman, Louis Vernacchio, Jorge Plutzky, and Annette L. Baker
  • DOI: 10.1373/clinchem.2012.182089

Autoimmune Diseases: Early Diagnosis and New Treatment Strategies

  • Moderators: Danijela Konforte and Eleftherios P. Diamandis
  • Experts: Walther J. van Venrooij, Rik Lories, and Michael M. Ward
  • DOI: 10.1373/clinchem.2012.189480

Thyroid Function during Pregnancy: Who and How Should We Screen?

  • Moderator: Ann M. Gronowski
  • Experts: James Haddow, Sarah Kilpatrick, John H. Lazarus, and Roberto Negro
  • DOI: 10.1373/clinchem.2012.185017

Ectopic Pregnancy

  • Moderators: Julie L.V. Shaw and Eleftherios P. Diamandis
  • Experts: Andrew Horne, Kurt Barnhart, Tom Bourne, and Ioannis E. Messinis
  • DOI: 10.1373/clinchem.2012.184168

Antibiotic Resistance: How Serious Is the Problem, and What Can Be Done?

  • Moderators: Alexander J. McAdam
  • Experts: David C. Hooper, Alfred DeMaria, Brandi M. Limbago, Thomas F. O'Brien, and Betsy McCaughey
  • DOI: 10.1373/clinchem.2011.181636

Altering the Landscape for Women in Clinical Chemistry: Perspectives from Multigenerational Leaders

  • Moderators: Shannon Haymond and Amy K. Saenger
  • Experts: Helen M. Free, Jocelyn M. Hicks, Marilyn A. Huestis, Rita Horvath, and Corinne R. Fantz
  • DOI: 10.1373/clinchem.2011.174284

The Obesity Epidemic

  • Moderators: Jennifer Shea and Eleftherios P. Diamandis
  • Experts: Arya M. Sharma, Jean-Pierre Després, Shereen Ezzat, and Frank Greenway
  • DOI: 10.1373/clinchem.2011.180976

Liquid Chromatography-Tandem Mass Spectrometry or Automated Immunoassays: What Are the Future Trends in Therapeutic Drug Monitoring?

  • Moderators: Gunnar Brandhorst and Michael Oellerich
  • Experts: Gregory Maine, Paul Taylor, Gerhard Veen, and Pierre Wallemacq
  • DOI: 10.1373/clinchem.2011.167189

Is Leadership a Noun or Verb?

  • Moderator: Thomas M. Annesley
  • Experts: James S. Hernandez, Angie Morgan, Ora Pescovitz, and Ian Wright
  • DOI: 10.1373/clinchem.2011.165639

How Well Are We Training the Next Generation of Clinical Pathologists and Clinical Laboratory Directors? A Global Perspective

  • Moderator: Mitchell G. Scott
  • Experts: Brian R. Smith, Alan H.B. Wu, Ian S. Young, Mario Plebani, and Rossa W.K. Chiu
  • DOI: 10.1373/clinchem.2011.171199

Newborn Screening for Metabolic Disorders: How Are We Doing, and Where Are We Going?

  • Moderator: Michael J. Bennett
  • Experts: Piero Rinaldo, Bridget Wilcken, Kenneth A. Pass, Michael S. Watson, and Ronald J.A. Wanders
  • DOI: 10.1373/clinchem.2011.171215

The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers

  • Moderators: Fred S. Apple and David Morrow
  • Experts: Christian Zaugg, David Hickey, Michelle Zaharik, John J. Blackwood, and Kirsten Jakobsen
  • DOI: 10.1373/clinchem.2011.165860


Invest or Not to Invest ... Not Always an Easy Question to Answer

  • Moderator: Susan Evans
  • Experts: Emery Stephans, Avi Kulkarni, Aaron Geist and Quintin Lai
  • DOI: 10.1373/clinchem.2010.152132

Direct-to-Consumer Genetic Testing: Reliable or Risky?

  • Moderators: David H. Spencer and Christina Lockwood
  • Experts: Eric Topol, James P. Evans, Robert C. Green, Elizabeth Mansfield, and Zivana Tezak
  • DOI: 10.1373/clinchem.2011.167197

Circulating Cancer Cells and Their Clinical Applications

  • Moderator: Eleftherios P. Diamandis
  • Experts: Klaus Pantel, Howard I. Scher, Leon Terstappen, and Evi Lianidou
  • DOI: 10.1373/clinchem.2011.166678

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

  • Moderator: Andrew N. Hoofnagle
  • Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
  • DOI: 10.1373/clinchem.2010.158311

Clinical Applications for Vitamin D Assays: What Is Known and What Is Wished for

  • Moderator: Michael Kleerekoper
  • Experts: Rosemary L. Schleicher, John Eisman, Roger Bouillon, Ravinder J. Singh and Michael F. Holick
  • DOI: 10.1373/clinchem.2010.154997

Oral Fluid Testing: Promises and Pitfalls

  • Moderator: Marilyn A. Huestis
  • Experts: Alain Verstraete, Tai C. Kwong, Jorg Morland, Michael J. Vincent, and Raphael de la Torre
  • DOI: 10.1373/clinchem.2010.152124

Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy

  • Moderators: Maria Diamandis Pasic and Eleftherios P. Diamandis
  • Experts: JoAnne McLaurin, David M. Holtzman, Gerold Schmitt-Ulms, and Rémi Quirion
  • DOI: 10.1373/clinchem.2011.161828

Individually Tailored Immunosuppression: Is There a Role for Biomarkers?

  • Moderators: Gunnar Brandhorst and Michael Oellerich
  • Experts: Mercè Brunet, Richard Kowalski, Alexander Vinks and Pierre Wallemacq
  • DOI: 10.1373/clinchem.2010.159871

 The Quest for Clean Competition in Sports: Are the Testers Catching the Dopers?

  • Moderator: Anthony W. Butch
  • Experts: John A. Lombardo, Larry D. Bowers, Julie Chu and David A. Cowan
  • DOI: 10.1373/clinchem.2010.155002

 The Use of Human Tissues in Research: What Do We Owe the Research Subjects?

  • Moderator: Ann M. Gronowski
  • Experts: Jack Moye, Jr., David S. Wendler, Arthur L. Caplan and Michael Christman
  • DOI: 10.1373/clinchem.2010.154989


Cancer Genomes

  • Moderator: Eleftherios P. Diamandis
  • Experts: Thomas Hudson, Olli Kallioniemi, Edison T. Liu and Carlos López-Otín
  • DOI: 10.1373/clinchem.2010.152140

Nanotechnology: Improving Clinical Testing?

  • Moderators: Paolo Fortina and Larry J. Kricka
  • Experts: Dawn Bonnell, Amit Kulkarni, Joseph Wang, Yuri Miyahara, and David Ure
  • DOI: 10.1373/clinchem.2009.138750

Epigenomics-Based Diagnostics

  • Moderator: Eleftherios P. Diamandis
  • Experts:  David Sidransky, Peter W. Laird, Paul Cairns and Bharati Bapat
  • DOI: 10.1373/clinchem.2010.148007

Direct-to-Consumer Genotyping: Are We Ready for a Brave New World?

  • Moderators: Mark A. Cervinski  and Gregory J. Tsongalis
  • Experts:  Lew Bender, Lawrence M. Silverman, Mary Bet Dinulos, Jim Nickel and Wayne Grody
  • DOI: 10.1373/clinchem.2009.138743

High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?

  • Moderator: Fred S. Apple
  • Experts:  Alan Wu, Paul Collinson, Allan Jaffe and David Morrow
  • DOI: 10.1373/clinchem.2009.138727

KRAS Mutation Detection: A New Look at an Old Gene 

  • Moderators: Joel A. Lefferts and Gregory J. Tsongalis
  • Experts:  Arief A. Suriawinata, William K. Funkhouser, Marc Ladanyi, Jan A. Nowak and J. Marc Pipas
  • DOI: 10.1373/clinchem.2009.138735

Microtechnology in the Clinical Laboratory: Will It Solve Analytical Problems, and When Will It Make an Impact?

  • Moderator: Peter Wilding
  • Experts: Sabeth Verpoorte, M. Allen Northrup, Paul Yager, Stephen Quake and James Landers
  • DOI: 10.1373/clinchem.2009.138719

Prostate Cancer Screening with Prostate-Specific Antigen Testing: More Answers or More Confusion?

  • Moderator: Eleftherios P. Diamandis
  • Experts:  Patrick Walsh, Klaus Jung, William Catalona and Neil Fleshner
  • DOI: 10.1373/clinchem.2009.140046

Detection of Biological Agents Used for Terrorism: Are We Ready?

  • Moderator: Mark Kellogg
  • Experts:  Mark Hollis, Cheryl Gauthier, and Tom O'Brien
  • DOI: 10.1373/clinchem.2009.139493


Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?

  • Moderator: Eleftherios P. Diamandis
  • Experts: Karl V. Voelkerding, Rade Drmanac, David Agus and John McPherson
  • DOI: 10.1373/clinchem.2009.133389

Clinical Assays for Human Chorionic Gonadotropin: What Should We Measure and How?

  • Moderator: Ann M. Gronowski
  • Experts: Catherine Sturgeon, Ulf-Håkan Stenman, Glenn D. Braunstein, Anthony W. Butch and David A. Cowan
  • DOI: 10.1373/clinchem.2009.133595

Tight Glucose Control in Critically Ill Patients: Should Glucose Meters Be Used?

  • Moderator: David B. Sacks
  • Experts: Greet Van den Berghe, Sue Kirkman, Gerald Kost, Ron Ng and Sverre Sandberg
  • DOI: 10.1373/clinchem.2009.131318

Protein Quantification by Mass Spectrometry: Is It Ready for Prime Time?

  • Moderator: Eleftherios P. Diamandis
  • Experts: Samir Hanash, Mary Lopez, Steven Carr, and Emanuel F. Petricoin III
  • DOI: 10.1373/clinchem.2009.128058 

Mass Spectrometry in the Clinical Laboratory: How Have We Done, and Where Do We Need to Be?

  • Moderator: Thomas Annesley
  • Experts:  Joseph Majzoub, Ann Hsing, Alan Wu, Alan Rockwood and Donald Mason
  • DOI: 10.1373/clinchem.2009.127522
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