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Clinical Chemistry
Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory. In addition to being the most cited journal in the field, Clinical Chemistry has the highest Impact Factor at 7.8 among journals of clinical chemistry, clinical (or anatomic) pathology, analytical chemistry, and the subspecialties, such as transfusion medicine, and clinical microbiology.
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August 2014
ON THE COVER: Model of Human Hemoglobin. Imagine the days when theses and dissertations were required to be written in Latin. In his 1825 Commentatio de vera materiae sanguini purpureum colorem impertientis natura, Johann Friederich Engelhart proposed the molecular mass of hemoglobin to be an astonishingly large 16,000 daltons per iron. No respectable scientist of the time believed that molecules could be that large. We now know that hemoglobin has a mass of ~᷉64,000 daltons, is the major oxygen-carrying component of blood, and can bind with glucose to form glycated hemoglobin (most commonly measured as Hb A1c). Because Hb A1c is routinely measured for diagnosing diabetes and prediabetes, as well as monitoring mean glycemia, it is important that Hb A1c results be reliable. But how well do existing Hb A1c assays perform? This month’s issue of Clinical Chemistry contains the results from 2 studies of Hb A1c assay performance, plus an accompanying editorial that discusses both of the studies. (See pages 1031, 1062, and 1073.) ©Martin McCarthy. Reproduced with permission.