American Association for Clinical Chemistry
Better health through laboratory medicine
May 2008 Mentor of the Month: John Savory
John Savory, PhD

Dr. Savory was born in Lancashire, England, in 1936.  He received a B.Sc. honors degree in chemistry (1958) and the Ph.D. degree in organic chemistry (1961) from the University of Durham, England.

He trained in clinical chemistry at the University of Washington, Seattle, from 1964-66 under the direction of Dr. Alex Kaplan.  From 1966-72 he was director of clinical chemistry and microscopy at the University of Florida College of Medicine, where he held the academic appointments of instructor, assistant professor, and finally associate professor of pathology.  From 1972-77 he was director of clinical chemistry and radioassay-endocrine laboratories and professor of medicine, pathology, and biochemistry at the University of North Carolina at Chapel Hill.  From 1977-2003, he was professor of Pathology and Biochemistry and Molecular Genetics at the University of Virginia, Charlottesville and director of the Core Laboratory at University of Virginia Health Sciences Center, Charlottesville. Having retired in 2003, he is Professor Emeritus of Pathology at the University of Virginia.

His research interests have encompassed a variety of methodological and clinical areas, resulting in the authorship or co-authorship of over 360 publications.

Early work involved protein assays, particularly the development of nephelometric immunochemical methods for specific proteins.  His research group first described the use of forward light scattering with a laser light source for these assays.  He also has developed numerous methods for the centrifugal analyzer and is co-editor of an AACC book, Methods for the Centrifugal Analyzer. A continuing interest has been trace metal metabolism, and he was one of the pioneers in the use of electrothermal AA for metal measurements in biological materials.  He developed a GC/MS procedure for prostaglandins for of the role of these compounds in hypertension and cancer. His most recent interest focused on aluminum toxicity and its role in neurodegeneration involving mitochondrial and endoplasmic reticulum stress in neuronal apoptosis.