Are there documented differences in the dosing of cyclosporine and tacrolimus based upon genetic differences in CYP3A5 expressions or MDR1 gene expression?
Hyderabad, AP, India

William Evans, PharmD
A pubmed search of tacrolimus and CYP3A5 produces 77 publications. A PubMed search of cyclosporine and CYP3A5 produces 55 publications. I have pasted two of these citations below, but the person asking this question should look at all of these papers. Hope this answers the question.