American Association for Clinical Chemistry
Better health through laboratory medicine
November 2008 Mentor of the Month Q&A Session: William Evans
Welcome to SYCL's Mentor of the Month.  Questions and Answers will be displayed below...

Are there documented differences in the dosing of cyclosporine and tacrolimus based upon genetic differences in CYP3A5 expressions or MDR1 gene expression?
Hyderabad, AP, India

William Evans, PharmD
A pubmed search of tacrolimus and CYP3A5 produces 77 publications. A PubMed search of cyclosporine and CYP3A5 produces 55 publications. I have pasted two of these citations below, but the person asking this question should look at all of these papers. Hope this answers the question.