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Purification of anlalytes using high affinity antibodies is an age old and well accepted method in biochemical analysis. By obtaining highly purified form of analyte through immunoextraction it may be easier to choose the ionic fragment that is unique to the analyte, while standardizing the methods for LC/MS, rather than looking for the unique ionic fragment in the sea of fragments obtained when complex matrix systems are used. The LC/MS scientist need not spend too much of his/her energy to find out the correct combination of settings to get that unique ionic fragment
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