Dr. Chace: Thank you for this informative piece and for mentioning the pioneering work performed by Dr. Robert Guthrie. I asked Dr. Guthrie once whether he felt his biggest contribution was the dried blood spot as a working specimen for metabolic testing or the various tests he developed using the DBS. He said without hesitation that it was the DBS itself. Little did he know that investigators would go on to use it for DNA isolation, or, on the counterproductive side, that states in the U.S. would legislate to destroy stores of DBS preventing important test development and research going forward.
Georgirene D. Vladutiu, Ph.D.
Director, The Robert Guthrie Biochemical & Molecular Genetics Laboratory