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DBS is being explored for islet autoantibody testing to expand screening in studies such as the Type 1 Diabetes TrialNet study. However such assays are very challenging because such autoantibodies are usually in very low concentration and require immunoprecipitation methods. For example see: Persson A, Becker C, Hansson I, Nilsson A, Törn C. Comparison of measurements of autoantibodies to glutamic acid decarboxylase and islet antigen-2 in whole blood eluates from dried blood spots using the RSR-enzyme linked immunosorbent assay kits and in-house radioimmunoassays. Exp Diabetes Res. 2010;2010:173652.
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