American Association for Clinical Chemistry
Better health through laboratory medicine
NACB - Scientific Shorts
NACB - Scientific Shorts (formerly NACB Blog)
By Dustin Bunch
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Matrix effects are regarded as the Achilles’ heel of clinical liquid chromatography tandem mass spectrometry (LC-MS/MS). Our laboratory has been developing clinical LC-MS/MS assays since 2006. To aid with assay validation, a protocol was established that included a serious investigation of matrix e...(Read More)
By Xuan Mu, PhD
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Cystic Fibrosis (CF) is one of the most common inherited disorders, primarily caused by mutations of a single gene, CF transmembrane conductance regulator (CFTR). An estimated 1.2 million individuals are tested for CF every year in the US (1). Over 127 mutations are associated with the pathogenesis...(Read More)
By Angela M. Ferguson, Ph.D., DABCC, FACB
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Clinical Impact of the BuBc Slide RecalibOrtho Clinical Diagnostics’ method of measuring bilirubin is unique when compared to other commonly used methods.  The difference between the methods is the way different bilirubin fractions are measured or calculated.  Total bilirubin is measured with the T...(Read More)
By Dina Greene, PhD
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This week our blog post is from the 2013 George Grannis Award Winner, Dina Greene.  Congratulations to Dr. Greene on this great accomplishment! When I began working at my current institution I was surprised to learn that we perform all of our hemoglobinopathy screens using both HPLC and isoelectri...(Read More)
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